Investigating how type 1 diabetes affects brain development in young children
Official title: Evaluating Neurocognitive Complications of Type 1 Diabetes (T1D) and Potential Risk and Protective Factors in Pre-Pubertal Children- New York University Clinical Center
Funded at New York University School of Medicine · NIH-10975293 · Data updated 2026-11-12
This study is looking at how type 1 diabetes affects the brain and thinking skills in young kids, and it’s inviting children with diabetes and those without to help us learn more by doing some fun brain tests and scans over a couple of years.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $287,332 |
| NIH project number | 1U01DK140791-01 |
| Project ID | NIH-10975293 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are prepubertal children aged 0-11 years, particularly those recently diagnosed with type 1 diabetes.
✕Less likely to help
Patients who are older than 11 years or those without a diagnosis of type 1 diabetes may not benefit from this research.
What this research studies
This research focuses on understanding the neurocognitive complications associated with type 1 diabetes (T1D) in prepubertal children. It aims to enroll up to 1,000 children, half of whom have been diagnosed with T1D within the last year. Participants will undergo MRI scans and cognitive tests at the start and again at intervals of 18 months to assess changes in brain development and cognitive function. The study will also collect biomedical data to explore how factors like blood sugar control and episodes of diabetic ketoacidosis impact cognitive outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive issues in children with type 1 diabetes.
How similar studies have gone: Previous research has indicated that cognitive dysfunction is a concern in children with diabetes, suggesting that this investigation builds on established findings.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Gallagher, Mary Patricia — New York University School of Medicine
- Study coordinator: Gallagher, Mary Patricia
Related research
Other NIH-funded projects on the same topics.
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Understanding brain changes in kids with new Type 1 diabetes
A multicenter study will follow young children with Type 1 diabetes and similar peers without diabetes to look for factors that influence brain development and thinking skills.
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Neurocognitive health in young kids with Type 1 diabetes and factors that help or hurt
A study following young children with Type 1 diabetes to understand how the condition affects thinking skills and behavior, and what factors might protect or worsen these effects.
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Understanding Brain Changes in Children with Type 1 Diabetes
This research aims to understand how Type 1 Diabetes affects brain development and thinking skills in children.
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Brain Health in Young Children with Type 1 Diabetes
This project looks at how Type 1 Diabetes affects brain development and thinking skills in young children.
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Improving access to continuous glucose monitoring for children with type 1 diabetes.
This study is looking at how things like race and income affect whether kids with type 1 diabetes can use continuous glucose monitors (CGMs), and it aims to find ways to make sure all children have better access to this helpful technology for managing their diabetes.
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Understanding how Type 1 Diabetes affects brain development in children
This study is looking at how Type 1 Diabetes affects the thinking skills of young kids, exploring how things like high blood sugar can impact their brain development, so we can better understand and support children who might struggle with attention, learning, and memory.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.