Condition

Pre Diabetes clinical trials and research

• 29Clinical trials
• 4NIH research projects
• 18Countries

Newest Pre Diabetes clinical trials

All recruiting trials (29)

• High-Intensity Interval Training vs. Continuous Endurance Training in Prediabetes

  This study tests whether short bursts of intense exercise or steady, longer workouts can improve blood sugar control and fitness in people with prediabetes.

  Recruiting Riphah International University · Lahore, Punjab Province · NCT07713030

• 7-Ketolithocholic Acid for people with prediabetes

  This study tests whether 7-Ketolithocholic Acid, used with a low-sugar, reduced-calorie diet and more exercise, can lower fasting blood sugar in adults with prediabetes.

  Recruiting at 8 sites ICE S.p.A. · Bordighera and 7 other locations · NCT07650123

• Continuous glucose monitoring to help adults with prediabetes manage blood sugar

  This study will try wearing a continuous glucose monitor to help adults in Singapore with prediabetes change behaviors and manage blood sugar compared with usual health coaching.

  Recruiting at 2 sites SingHealth Polyclinics · Singapore and 1 other locations · NCT07371546

• Healthy beef-centric diet versus a Healthy U.S.-Style diet for adults with pre-diabetes or metabolic syndrome

  This 5-week randomized test will see if a beef-centered, low-carbohydrate diet reduces inflammation and improves metabolic health in adults with pre-diabetes or metabolic syndrome.

  Recruiting National Cattlemen's Beef Association, a contractor to the Beef Checkoff · Guelph, Ontario - on · NCT07269847

• EMR prompts in primary care to help prevent prediabetes from becoming diabetes

  This project will test whether electronic medical record prompts for doctors in primary care help adults with prediabetes avoid developing diabetes.

  Recruiting National University Polyclinics, Singapore · Singapore · NCT07252700

• Long-term effects of time-restricted eating on cardiometabolic health

  This 54-week study will test if limiting daily eating to an 8–12 hour window helps adults with metabolic syndrome and pre-diabetes improve blood sugar, cholesterol, blood pressure, and body composition.

  Recruiting Phase 2 University of California, San Diego · La Jolla, California · NCT07189234

• UK islet autoantibody registry for early Type 1 diabetes

  This UK registry collects health and antibody information from people with one or more islet autoantibodies to track who develops Type 1 diabetes and to connect them with monitoring or prevention options.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT07125365

• INNODIA Family & Friends Early-Stage Type 1 Diabetes Detection

  This program tests blood autoantibody screening to find people aged 1 to 45 who, because they have a relative or close friend with Type 1 diabetes, may be at higher risk of developing T1D.

  Recruiting at 20 sites INNODIA iVZW · Vienna and 20 other locations · NCT07118098

• Sisters of Heart: community health worker support to improve heart health in migrant farmworker women

  This trial tests whether peer support and help accessing community resources from community health workers can reduce stress and improve heart health measures in Spanish- or English-speaking migrant farmworker women aged 18–45.

  Recruiting Emory University · Ellenton, Georgia · NCT07111026

• More Health, Less Diabetes: exercise and education program

  This program will test whether supervised online or in-person exercise plus health education over 12 months can lower blood sugar and help prevent type 2 diabetes in adults with prediabetes.

  Recruiting Faculdade de Motricidade Humana · Lisbon, Lisbon District · NCT07079722

• Monitoring blood sugar levels in people with and without prediabetes

  This study is testing how blood sugar levels differ between people with prediabetes and those without to help improve diabetes management in the future.

  Recruiting Abbott Diabetes Care · Bend, Oregon · NCT06921902

• Program to prevent young onset diabetes using genetic and clinical assessments

  This study is testing a program that uses genetic and health checks to help young adults at risk of diabetes prevent the disease and learn more about their health.

  Recruiting Asia Diabetes Foundation · Hong Kong · NCT06693934

• Effects of Lactate on Nutrient Absorption in Pre-Diabetes

  This study is testing if taking lactate can help people with pre-diabetes absorb nutrients better and manage fat after meals.

  Recruiting University of Aarhus · Aarhus · NCT06668714

• Fat‑targeted treatment with pioglitazone or tirzepatide for normal‑weight type 2 diabetes

  This test will see if two fat‑targeting medicines, pioglitazone and tirzepatide, can improve insulin resistance and fat distribution in adults with normal‑weight type 2 diabetes compared with overweight people with diabetes and normal‑weight people without diabetes.

  Recruiting Phase 4 Stanford University · Palo Alto, California and 1 other locations · NCT06657209

• Effects of Grape Seed Extract on Blood Pressure and Metabolic Health

  This study is testing if taking a daily grape seed extract supplement can help people with high blood pressure and pre-diabetes improve their heart health and metabolism.

  Recruiting Clinical Nutrition Research Center, Illinois Institute of Technology · Chicago, Illinois · NCT06555952

• Lactose-containing versus lactose-free milk for diabetes prevention in people with lactase non-persistence

  This trial will test whether drinking lactose-containing milk instead of lactose-free milk for 12 weeks changes gut bacteria and improves blood sugar in people with lactase non-persistence and prediabetes.

  Recruiting Albert Einstein College of Medicine · The Bronx, New York · NCT06513026

• Using a special light treatment to manage periodontitis in diabetic patients

  This study tests whether a special light treatment can help diabetic patients manage gum health and plaque better than regular oral care methods.

  Recruiting Wellbeing Services County of Pirkanmaa · Tampere, Pirkanmaa · NCT06486012

• Helping people with prediabetes and obesity improve their health

  This study is testing different affordable treatments to help people with prediabetes and obesity lower their blood sugar and lose weight.

  Recruiting Phase 1 The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT06446531

• Preventing type 2 diabetes in high-risk adults in Brazil

  This study is testing a diabetes prevention program in Brazil to see if it can help high-risk adults avoid developing type 2 diabetes over three years.

  Recruiting at 2 sites Beneficência Portuguesa de São Paulo · Goiânia, Goiás and 1 other locations · NCT06426277

• Assessing pancreatic beta cell mass and function in diabetes using PET imaging

  This study is testing a new imaging tool to see how well the insulin-producing cells in the pancreas are working in people with type 1 and type 2 diabetes, as well as those with prediabetes.

  Recruiting Azienda Ospedaliero-Universitaria di Parma · Parma, Pr · NCT05662189

• Using sit-stand desks to improve health in sedentary workers

  This study is testing if using sit-stand desks can help people with prediabetes, obesity, and metabolic syndrome who have desk jobs improve their health.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT05585190

• Testing a nutrition program to lower blood sugar levels

  This study is testing a personalized nutrition program to see if it can help people with prediabetes or diabetes lower their blood sugar levels over 90 days.

  Recruiting Viome · Bothell, Washington · NCT05465616

• Effects of Mirabegron and Tadalafil on Glucose Tolerance in Prediabetics

  This study is testing if the medications mirabegron and tadalafil can help people with prediabetes improve their blood sugar levels over 14 weeks.

  Recruiting Phase 4 University of Kentucky · Lexington, Kentucky · NCT05051436

• Breaking up sedentary time to improve glucose control in people at risk for type 2 diabetes

  This study tests if taking short breaks for 5-minute physical activities can help people at risk for type 2 diabetes control their blood sugar better than just doing longer workouts.

  Recruiting Early Phase 1 University of Colorado, Denver · Aurora, Colorado · NCT05041491

• Understanding how puberty affects kidney health in youth with diabetes

  This study looks at how puberty affects kidney health in teenagers with type 2 diabetes and obesity to see if the changes during this time can harm their kidneys.

  Recruiting at 2 sites Seattle Children's Hospital · Aurora, Colorado and 1 other locations · NCT05008276

• Using semaglutide to help women with a history of gestational diabetes return to normal blood sugar levels

  This study is testing if a medication called semaglutide can help women who had gestational diabetes and currently have blood sugar issues get back to normal levels after giving birth.

  Recruiting Phase 4 Woman's · Baton Rouge, Louisiana · NCT04873050

• Understanding Fatigability in People with Diabetes

  This study is testing how different exercise methods can help people with pre-diabetes and type 2 diabetes feel less tired during workouts and improve their overall muscle health.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT04442451

• Impact of Type 2 Diabetes on Muscle Loss and Recovery in Older Adults

  This study is testing how type 2 diabetes affects muscle loss and recovery in older adults during bed rest to see if it helps us understand why they lose muscle faster.

  Recruiting AdventHealth Translational Research Institute · Orlando, Florida · NCT03761446

• Cohort study on obesity, diabetes, and inflammation across different ethnicities

  This study is trying to understand how obesity, diabetes, and inflammation are connected across different ethnic groups by gathering health information and samples from 350 adults with stable weight.

  Recruiting University of California, San Francisco · San Francisco, California · NCT03022682

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Multi-dimensional approach to reduce weight and health disparities in young adults

  A university-based program aims to create tailored, community-informed weight loss and health-promotion strategies for college-age adults in limited-resource settings.

  NIH research North Carolina Central University · Durham, United States · NIH-11387615

• How prediabetes and type 2 diabetes begin in young people

  This project tests whether the diabetes medicine liraglutide can protect insulin-making cells and reduce fatty liver in obese youth with early blood sugar problems.

  NIH research Yale University · New Haven, United States · NIH-11161546

• Reducing excess weight and early diabetes risk in young adults

  This project offers community-tailored and digital weight-management programs to help college students and other young adults in limited-resource areas lower excess weight and reduce early diabetes risk.

  NIH research North Carolina Central University · Durham, United States · NIH-11111295

• Investigating the link between obesity, insulin resistance, and asthma severity

  This study is looking at how insulin resistance, pre-diabetes, and diabetes impact asthma control in people with obesity who have asthma, especially those getting weight loss surgery, to help understand how these conditions might affect their breathing and overall health.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11072964

Related topics

Quick answers

How many Pre Diabetes clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (16 trials), Italy (3 trials), Singapore (2 trials), Canada (1 trial), Brazil (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 1: 1, Phase 2: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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