Islet re-transplantation after prior graft failure in adults with type 1 diabetes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter retrospective study analyzes adults with type 1 diabetes who had a prior beta-cell replacement and then received an islet re-transplant after graft failure. It examines safety and effectiveness, including graft survival and recurrent hypoglycemia, using data from several French university hospitals. The study notes concerns about alloimmunization from repeated donor exposure and aims to clarify outcomes after second islet transplantation. Interventions are not specified in detail, and eligibility requires documented graft failure and available clinical data. The lead sponsor is University Hospital, Montpellier, with collaboration from additional French centers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Diagnosis of type 1 diabetes
* Prior beta-cell replacement therapy : islet transplantation or pancreas transplantation
* Islet re-transplantation performed after 2005
* Islet re-transplantation performed after documented beta cell graft failure, defined by undetectable C-peptide and/or recurrence of severe hypoglycemia on insulin therapy
* Availability of clinical and biological data required for assessment of study outcomes

Exclusion Criteria:

* Missing or incomplete data preventing assessment of the primary outcome
* Patients who did not meet inclusion criteria

Where it's running

• Montpellier University Hospital
  Montpellier, France Recruiting

Study contacts

• Study coordinator: Orianne OV Villard, MD
• Email: orianne.villard@chu-montpellier.fr
• Phone: +33 467 338 382

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.