How exercising in hot weather affects blood sugar in people with type 1 diabetes.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, crossover, counterbalanced study has participants complete two laboratory visits performing 40 minutes of moderate-intensity exercise under either temperate (20°C, 50% humidity) or hot (40°C, 50% humidity) conditions. Visits are identical except for temperature, separated by 24 hours, and use continuous glucose monitoring to track blood glucose during exercise and for 30 minutes afterwards. Eligible adults aged 18–65 with type 1 diabetes for more than one year who regularly perform endurance exercise and use multiple daily injections, an insulin pump, or a hybrid closed-loop system will be enrolled. Testing takes place in the Research Institute for Sport and Exercise Sciences laboratories at Liverpool John Moores University.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* T1D diagnosis more than 1 years ago (to ensure participants are out of the honeymoon period)
* Using insulin therapy with multiple daily injections (MDI), insulin pump (pump), or hybrid closed-loop (HCL)

  o If using a HCL system have experience of using a pre-programmed basal rate in manual mode during exercise
* Aged 18-65 years
* Regularly engaged in endurance exercise (training at least twice per week for ≥30 minutes per session)

Exclusion Criteria:

* Pregnancy
* \<6 months postpartum or stopped breastfeeding \<1 month before recruitment
* Existing cerebrovascular or cardiovascular disease
* Significant history of hyperglycaemia (HbA1c \>85 mmol/mol)
* History of severe hypoglycaemia requiring third party assistance within the last 3 months
* Body weight \<36.5kg
* Difficulty swallowing tablets
* Appointment for an MRI test that cannot be rescheduled
* Obstructive gastrointestinal disease
* History of gastrointestinal surgery
* Have an implanted medical device

Where it's running

• Liverpool John Moores University
  Liverpool, United Kingdom Recruiting

Study contacts

• Study coordinator: Matthew Cocks, PhD
• Email: m.s.cocks@ljmu.ac.uk
• Phone: 447540191292

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.