Condition

Type 1 Diabetes Mellitus clinical trials and research

• 58Clinical trials
• 4NIH research projects
• 27Countries

Newest Type 1 Diabetes Mellitus clinical trials

All recruiting trials (58)

• VV-14300: a gene therapy approach for adults with type 1 diabetes not well controlled on an automated insulin system

  This trial tests VV-14300 in adults with type 1 diabetes who aren’t reaching their blood sugar goals despite using an automated insulin delivery system.

  Recruiting Phase 1/2 Kriya Therapeutics, Inc. · Toronto and 1 other locations · NCT07831798

• New gene therapies VV-14299 and VV-14300 for adults with Type 1 Diabetes failing automated insulin delivery

  This study tests VV-14299 and VV-14300, or VV-14300 alone, in adults with long-standing Type 1 Diabetes whose blood sugar remains poorly controlled despite using an automated insulin delivery system.

  Recruiting Phase 1/2 Kriya Therapeutics, Inc. · Melbourne · NCT07829302

• Oral verapamil in newly diagnosed children and teens with type 1 diabetes

  This study tests whether taking verapamil by mouth can help preserve pancreatic beta cells and reduce insulin needs in kids and teens with recently diagnosed type 1 diabetes.

  Recruiting Phase 2/3 Ain Shams University · Cairo · NCT07804849

• Preventing device-related skin rashes in kids with type 1 diabetes using hydrocolloid vs silicone patches

  This study tests whether silicone-based or hydrocolloid patches help prevent recurring skin irritation from insulin pumps or CGMs in children and teens with type 1 diabetes.

  Recruiting Steno Diabetes Center Copenhagen · Copenhagen · NCT07767461

• AI-assisted remote insulin pump optimization for people with type 1 diabetes

  This study tests an AI-powered tool that suggests insulin pump settings for people with type 1 diabetes, with doctor-approved recommendations delivered to a mobile app.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT07732777

• Near-sensor insulin delivery with CGM in people with type 1 diabetes

  A small early-feasibility study tests a dual-port insulin patch pump that includes a CGM sensor to see if delivering insulin near the sensor affects glucose readings and whether an automated control algorithm can manage glucose.

  Recruiting Early Phase 1 ClinSurge Research · Toronto, Ontario · NCT07655076

• Next-Generation AID Algorithm for Type 1 Diabetes using Omnipod system

  This study tests a new automated insulin delivery algorithm with Omnipod M/S in people with type 1 diabetes to see if it can safely support glucose control.

  Recruiting Insulet Corporation · Christchurch · NCT07593625

• Effect of 4 Weeks of Desulfovibrio piger Probiotic on Immunological and Metabolic Parameters in Longstanding Type 1 Diabetes

  This trial tests whether taking Desulfovibrio piger as a daily probiotic for four weeks can change immune, inflammatory, and beta cell function markers in adults with long-standing type 1 diabetes who still have some residual beta cell activity.

  Recruiting at 2 sites Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam and 1 other locations · NCT07585994

• Omnipod 6 vs Omnipod 5: a head-to-head test in kids and adults with type 1 or type 2 diabetes

  This study tests whether the Omnipod 6 system improves blood sugar control compared with the Omnipod 5 in people with type 1 or type 2 diabetes who aren’t at goal.

  Recruiting at 11 sites Insulet Corporation · Los Angeles, California and 10 other locations · NCT07579702

• What factors help or stop teens with Type 1 diabetes from being physically active in Istanbul

  This observational project will see how individual, family, school, community, and policy-level factors relate to physical activity, social participation, and diabetes management in adolescents (9–18 years) with Type 1 diabetes who attend school in Istanbul.

  Recruiting Biruni University · Istanbul, Zeytinburnu · NCT07568028

• Dimethyl fumarate to preserve insulin-producing beta cells in adults with type 1 diabetes

  This study will try adding dimethyl fumarate to insulin to see if it helps preserve beta-cell function in adults 18–65 with type 1 diabetes who still make some insulin.

  Recruiting Phase 2/3 Nanjing Medical University · Nanjing, Jiangsu · NCT07548996

• Polycystic Ovary Syndrome in Type 1 Diabetes

  This study tests whether women with type 1 diabetes and PCOS differ from other groups in factors that drive androgen excess and what that means for health.

  Recruiting Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · Madrid, Madrid · NCT07490964

• Markers of early kidney and heart injury in children newly diagnosed with type 1 diabetes

  This study will test whether blood markers and heart ultrasound can find early kidney or heart injury in children aged 2–16 who are newly diagnosed with type 1 diabetes, comparing those with diabetic ketoacidosis, those without, and healthy children.

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki, Central Makedonia · NCT07483879

• Screening and management pathway for people at high risk of type 1 diabetes

  This project will try regular blood, urine, and stool tests to see if they can identify and guide care for people at high risk of type 1 diabetes, including patients and their close relatives.

  Recruiting Peking University First Hospital · Beijing, Beijing Municipality · NCT07468474

• AI-based analysis to find subgroups in adults with type 1 diabetes

  This project will use artificial intelligence on medical records and continuous glucose monitor data to see if there are distinct subtypes among adults with type 1 diabetes.

  Recruiting Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau · Barcelona, Barcelona · NCT07461805

• Cardiometabolic effects of non-nutritive sweeteners in Type 1 diabetes

  This study tests whether non-nutritive sweeteners in a 12-ounce cherry Gatorade drink affect blood sugar control and cardiovascular markers in teens and young adults with Type 1 diabetes.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT07434544

• Oxidative stress markers in adults with type 1 diabetes versus LADA.

  This project will see if blood markers of oxidative stress differ between adults with type 1 diabetes and adults with LADA.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Pavia · NCT07434154

• Post-meal glucagon before exercise to keep glucose from dropping in type 1 diabetes

  In adults with type 1 diabetes using an automated insulin delivery system, the study tests whether a small dose of glucagon given before exercise helps prevent or lessen drops in blood glucose during and after moderate exercise after a meal.

  Recruiting Phase 4 Steno Diabetes Center Copenhagen · Herlev · NCT07427251

• Pediatric Insulin Dose Calculator to Help Manage Type 1 Diabetes in Under-12s

  A digital tool that helps caregivers of children under 12 with Type 1 diabetes calculate insulin doses during meals, tested alongside standard care for 6 months.

  Recruiting at 2 sites Sultan Qaboos University · Mosul and 1 other locations · NCT07427134

• HbA1c accuracy in people with inflammatory arthritis on sulfasalazine

  This study tests whether HbA1c reliably reflects blood glucose in adults with inflammatory arthritis who are treated with sulfasalazine, by comparing it to continuous glucose monitoring.

  Recruiting Central Jutland Regional Hospital · Silkeborg, Central Jutland · NCT07416656

• Game-based education for children with type 1 diabetes

  We will test if a game-based education program helps children aged 8–12 with type 1 diabetes improve their health knowledge and quality of life.

  Recruiting KTO Karatay University · Ankara, Yenimahalle · NCT07409701

• Postmarket monitoring of twiist automated insulin delivery for people with Type 1 diabetes

  This project will collect real-world data from people age 6 and older with Type 1 diabetes who recently started using the twiist automated insulin delivery system to see how it works for them over 12 months.

  Recruiting Deka Research and Development · Tampa, Florida · NCT07356089

• CareSens Air 3 continuous glucose monitor accuracy and precision in adults with type 1 diabetes

  This study will test whether the CareSens Air 3 continuous glucose monitor gives accurate and consistent glucose readings for adults with type 1 diabetes during a 16-day wear period.

  Recruiting at 2 sites i-SENS, Inc. · Escondido, California and 3 other locations · NCT07296276

• Tirzepatide added to an automated insulin delivery system to help adults with type 1 diabetes manage blood sugar

  This study tests whether once-weekly tirzepatide can help adults with type 1 diabetes use their insulin pumps more easily, possibly reducing the need to count carbohydrates at meals.

  Recruiting Phase 2/3 McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec and 3 other locations · NCT07284511

• MICRON: Comparing heart and kidney oxygen use in people with type 1 diabetes

  This project tests whether a multifactorial treatment versus standard care changes heart and kidney oxygen use in people with long-standing type 1 diabetes who have kidney or cardiovascular risk.

  Recruiting at 5 sites University of Aarhus · Aarhus N and 4 other locations · NCT07270172

• Afrezza plus basal insulin for newly diagnosed Type 1 diabetes in youth

  This trial tests whether adding inhaled Afrezza to daily basal insulin helps 10 to 17-year-olds newly diagnosed with type 1 diabetes control their blood sugar and feel better about treatment.

  Recruiting at 10 sites Phase 2 Mannkind Corporation · Los Angeles, California and 9 other locations · NCT07224321

• Teplizumab versus ATG to delay Stage 3 type 1 diabetes

  This trial tests whether ATG can delay or prevent Stage 3 type 1 diabetes as well as or better than teplizumab in people aged 4 to 34 with Stage 2 disease.

  Recruiting at 6 sites Phase 2 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Aurora, Colorado and 5 other locations · NCT07216391

• Fake-carb entries with the MiniMed 780G in children and adolescents with type 1 diabetes

  This test will see if entering 'fake' carbohydrate amounts into the MiniMed 780G changes blood sugar control in children and adolescents (ages 7–18) with type 1 diabetes who already use the device.

  Recruiting Athens General Children's Hospital "Pan. & Aglaia Kyriakou" · Athens, Attica and 2 other locations · NCT07179471

• AI-based retinopathy screening for children with type 1 diabetes

  This study tests whether an AI software can accurately screen for diabetic retinopathy in children with type 1 diabetes.

  Recruiting University Hospital, Motol · Prague, Prague 5 · NCT07149142

• Improving metabolic indicators in adults with type 1 diabetes

  This program will try a structured 12-hour education course plus regular outpatient follow-up to see if adults with type 1 diabetes improve self-management and metabolic measures.

  Recruiting Peking University First Hospital · Beijing · NCT07144696

• Rezpegaldesleukin (NKTR-358) for people with new-onset type 1 diabetes

  This Phase 2 trial will test whether rezpegaldesleukin, given as a subcutaneous injection every two weeks, can help preserve insulin production in people newly diagnosed with type 1 diabetes.

  Recruiting at 14 sites Phase 2 National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · San Francisco, California and 14 other locations · NCT07142252

• Teplizumab versus placebo for recent-onset Stage 3 Type 1 diabetes in people aged 1–25

  This will test whether an IV course of teplizumab can improve blood sugar control and reduce the need for mealtime insulin over one year in people aged 1–25 who were recently diagnosed with stage 3 type 1 diabetes.

  Recruiting at 202 sites Phase 3 Sanofi · Scottsdale, Arizona and 201 other locations · NCT07088068

• Tailored four-week online self-compassion program for adults with diabetes

  This four-week online self-compassion program is being tested to see if it reduces diabetes-related distress and improves wellbeing for adults with Type 1 or Type 2 diabetes.

  Recruiting Canterbury Christ Church University · Bangor, Wales and 1 other locations · NCT07051005

• Inulin for blood sugar control and immune markers in adults with type 1 diabetes

  This 90-day trial will test whether taking daily inulin powder improves continuous glucose monitoring measures and immune markers in adults with type 1 diabetes who have less than 80% time in range.

  Recruiting at 2 sites Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam and 1 other locations · NCT07050888

• GNTI-122 cell therapy for adults recently diagnosed with type 1 diabetes

  This test uses an experimental cell therapy made from your own blood, called GNTI-122, to try to preserve insulin production in adults who were recently diagnosed with type 1 diabetes.

  Recruiting at 9 sites Phase 1 GentiBio, Inc · Duarte, California and 9 other locations · NCT06919354

• Basic blood and clotting tests in children with type 1 diabetes

  This study in children with type 1 diabetes will look at basic blood and clotting test results and compare them with healthy kids to see if there are differences related to diabetes.

  Recruiting Assiut University · Asyut, Asyut Governorate · NCT06897904

• Control‑IQ use and glucose control during regular exercise in teenagers with type 1 diabetes

  This project will see if the Control‑IQ automated insulin system helps teenagers with type 1 diabetes keep glucose levels in range during regular physical activity.

  Recruiting University of Messina · Messina, Italy · NCT06876207

• Skin barrier and subcutaneous changes from insulin pumps and glucose monitors in children

  This project will test, in children with type 1 diabetes who use insulin pumps or continuous glucose monitors, how those devices affect the skin and subcutaneous tissue and whether steps like rotation, barrier creams, or different adhesives help the skin recover.

  Recruiting Linkoeping University · Linköping · NCT06856954

• Tirzepatide for metabolic effects in adults with type 1 diabetes

  This study tests whether weekly tirzepatide can improve insulin sensitivity and metabolic responses in adults with type 1 diabetes compared with placebo over six weeks.

  Recruiting Phase 2 Victor Chang Cardiac Research Institute · Sydney, New South Wales · NCT06820281

• Tropocells autologous platelet-rich fibrin for healing mild-to-moderate neuroischemic diabetic foot ulcers

  This will test whether Tropocells autologous platelet-rich fibrin (PRF) helps close mild-to-moderate neuroischemic diabetic foot ulcers in adults with type 1 or type 2 diabetes.

  Recruiting at 2 sites Phase 2 Estar Medical dba Medical Technologies, LTD · Corpus Christi, Texas and 1 other locations · NCT06810726

• CNP-103 treatment for adolescents and young adults recently diagnosed with stage 3 type 1 diabetes

  This trial will test whether multiple doses of CNP-103, compared with placebo, help people ages 12–35 who were diagnosed with stage 3 type 1 diabetes within the past 6 months.

  Recruiting at 45 sites Phase 1/2 COUR Pharmaceutical Development Company, Inc. · Tucson, Arizona and 44 other locations · NCT06783309

• Reducing diabetes distress in teenagers

  This study is testing a new program to help teenagers with Type 1 Diabetes feel less stressed about their condition by comparing in-person and online support sessions.

  Recruiting Ann & Robert H Lurie Children's Hospital of Chicago · Chicago, Illinois · NCT06709755

• Using patients' own T cells to treat Type 1 Diabetes

  This study is testing whether using patients' own T cells can help treat Type 1 Diabetes by restoring the immune system's ability to protect insulin-producing cells.

  Recruiting Phase 1 The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT06708780

• Evaluating the Accu-Chek SmartGuide CGM for Diabetes Management

  This study is testing if the Accu-Chek SmartGuide continuous glucose monitor can help adults with Type 1 or insulin-dependent Type 2 diabetes manage their blood sugar levels better than traditional self-monitoring methods.

  Recruiting at 19 sites Hoffmann-La Roche · Gdansk and 19 other locations · NCT06704672

• Comparing carb counting to meal-size estimation for managing Type 1 Diabetes in adolescents

  This study is testing whether counting carbs or estimating meal sizes helps teenagers with Type 1 Diabetes manage their blood sugar better while using automated insulin delivery systems.

  Recruiting Rabin Medical Center · Petah Tikva · NCT06687434

• Using exercise to manage high blood sugar after missed insulin doses

  This study is testing if brisk walking after missing insulin can help young adults with type 1 diabetes keep their blood sugar levels in check.

  Recruiting Institut de Recherches Cliniques de Montreal · Montreal, Quebec · NCT06686329

• Reducing high insulin levels to improve heart and blood sugar health in type 1 diabetes

  This study is testing whether a new medication can help people with type 1 diabetes lower their insulin levels to improve their heart and blood sugar health.

  Recruiting Early Phase 1 Vanderbilt University Medical Center · Nashville, Tennessee · NCT06609356

• Investigating the safety and effectiveness of porcine pancreatic cells in patients with Type 1 diabetes

  This study is testing if using pig pancreas cells can help adults with tough-to-manage Type 1 diabetes feel better and avoid dangerous low blood sugar episodes.

  Recruiting Phase 1/2 Otsuka Pharmaceutical Factory, Inc. · Chicago, Illinois · NCT06575426

• Testing MTX228 for regrowing insulin-producing cells in Type 1 Diabetes

  This study is testing a new medication called MTX228 to see if it can help people with Type 1 Diabetes regrow insulin-producing cells and reduce their need for insulin.

  Recruiting Phase 2 University of Alberta · Edmonton, Alberta · NCT06474598

• Collaborative research on managing Type 1 Diabetes in China

  This study is trying to improve the care and treatment of people with Type 1 Diabetes in China by using new technology and education to help manage their condition better.

  Recruiting Second Xiangya Hospital of Central South University · Changsha, Hunan · NCT04096794

• Early diagnosis and care program for type 1 diabetes in children

  This study is testing a new screening program to help find type 1 diabetes early in children aged 2 to 10 in Bavaria to prevent serious health issues and support families better.

  Recruiting Helmholtz Zentrum München · Munich · NCT04039945

• Registry for individuals with type 1 diabetes in Canada

  This study is gathering information from people with type 1 diabetes in Canada to learn more about their experiences with low blood sugar episodes and how it affects their lives.

  Recruiting at 7 sites Institut de Recherches Cliniques de Montreal · Edmonton, Alberta and 6 other locations · NCT03720197

• Comparing insulin pump therapy to multiple daily insulin injections for young adults with type 1 diabetes

  This study tests whether using an insulin pump works better than daily insulin shots for young adults with type 1 diabetes who have trouble controlling their blood sugar.

  Recruiting Phase 4 University of Campania Luigi Vanvitelli · Naples · NCT03463564

• Long-term effects of immunomodulatory treatments in Type 1 Diabetes

  This study looks at people with Type 1 Diabetes who have tried certain treatments to see how long they can still make insulin and how their immune system changes over time.

  Recruiting at 8 sites National Institute of Allergy and Infectious Diseases (NIAID) · San Francisco, California and 11 other locations · NCT02734277

• Evaluating insulin therapy effects on lipoproteins in type 1 diabetes

  This study is testing how insulin therapy affects cholesterol levels in people who have just been diagnosed with type 1 diabetes over several years.

  Recruiting Poznan University of Medical Sciences · Poznan · NCT02306005

• Monitoring patients after islet transplant failure

  This study looks at patients who have lost their islet transplant for Type 1 Diabetes to see how stopping their immune-suppressing medications affects their antibody levels over the next 10 years.

  Recruiting University of Miami · Miami, Florida · NCT02000687

• Long-term follow-up for patients with functional islet transplants

  This study looks at how well islet transplants are working for people who had them in earlier trials, to see how they are doing over the long term.

  Recruiting University of Miami · Miami, Florida · NCT01999374

• Preventing new immune responses in islet transplant patients after graft loss

  This study is testing if switching islet transplant patients who lost their graft to a different medication can help prevent their immune system from reacting negatively to future transplants.

  Recruiting University of Miami · Miami, Florida · NCT01999361

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Fully automated artificial pancreas for managing type 1 diabetes

  A new fully automated insulin delivery system that predicts meals and uses faster-acting insulin to help people with type 1 diabetes keep blood sugar in range.

  NIH research University of Virginia · Charlottesville, United States · NIH-11159389

• Creating a fully automated system for managing blood sugar in Type 1 diabetes

  This study is working on a smart device that helps people with Type 1 diabetes manage their blood sugar automatically, so they won’t have to worry about counting carbs or announcing meals, making life a little easier for them.

  NIH research University of Virginia · Charlottesville, United States · NIH-10909039

• Investigating the impact of sleep on blood sugar management in young adults with type 1 diabetes.

  This study is looking at how sleep habits impact blood sugar control in young adults with type 1 diabetes, and it aims to find helpful ways for them to manage their diabetes better.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10636840

• Improving methods to encapsulate insulin-producing cells for treating Type 1 diabetes

  This study is looking at ways to better protect insulin-producing cells for people with Type 1 diabetes, so they can work well after being transplanted, with the hope of creating a more effective treatment for you.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-10543809

Related topics

Quick answers

How many Type 1 Diabetes Mellitus clinical trials are recruiting right now?

58, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (18 trials), Canada (8 trials), China (7 trials), Denmark (4 trials), Italy (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 1/2: 4, Phase 2/3: 3, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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