Understanding Brain Changes in Children with Type 1 Diabetes

Mapping Neurocognitive Complications of Pediatric Type 1 Diabetes (T1D) and Potential Risk and Protective Factors

NIH-funded research Univ of North Carolina Chapel Hill · NIH-11169695

This research aims to understand how Type 1 Diabetes affects brain development and thinking skills in children.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionUniv of North Carolina Chapel Hill NIH-funded
Lab location1 site (Chapel Hill, United States)
Project IDNIH-11169695 on NIH RePORTER

What this research studies

We want to learn why some children with Type 1 Diabetes experience changes in their thinking abilities. Our team of brain imaging experts and diabetes specialists will look at how Type 1 Diabetes impacts the developing brain. We believe that factors like high or low blood sugar, insulin resistance, and stress might play a role in these brain changes. By studying children over time, we hope to identify which children are most at risk and what factors contribute to these challenges.

Who could benefit from this research

Good fit: Ideal candidates for this research would be prepubertal children diagnosed with Type 1 Diabetes.

Not a fit: Patients who do not have Type 1 Diabetes or are adults would not directly benefit from this specific pediatric research.

Why it matters

Potential benefit: If successful, this work could help us prevent thinking difficulties in children with Type 1 Diabetes and identify those who need support the most.

How similar studies have performed: This project addresses a significant gap in our understanding, as there is a lack of long-term studies on how Type 1 Diabetes affects children's brains.

Where this research is happening

Chapel Hill, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.