Improving blood sugar control in type 1 diabetes using team care, technology, education and peer support

Glycemic Improvement With Team, Technology, Education and Peer Resources in Type 1 Diabetes-GLITTER Study

This program will try whether combining a care team, diabetes technologies (like CGMs and pumps), structured education, and peer support helps people with type 1 diabetes manage their blood sugar better.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 3000 (estimated)
• Sex: All
• Sponsor: Second Xiangya Hospital of Central South University (Academic / other)
• Locations: 10 sites (Beijing, Beijing Municipality and 9 other locations)
• Trial ID: NCT07097805 on ClinicalTrials.gov

What this trial studies

The GLITTER program implements a four-in-one management model that combines multidisciplinary clinical teams, structured education, peer support groups, and access to diabetes technologies. It is a multicenter, prospective cohort across several major hospitals in China and follows patients longitudinally to track metabolic control. Education is delivered through specialty clinics and local clinicians, while technology access (CGM and pumps) is offered but not mandated, and peer support is organized via patient communication groups. The aim is population-wide coverage and whole-disease-course management to increase the rate of patients reaching glycemic targets.

Who should consider this trial

Good fit: People of any age with a clinical diagnosis of type 1 diabetes who are on insulin therapy or meet diagnostic criteria such as early onset, diabetic ketoacidosis at presentation, low C‑peptide, or positive islet autoantibodies are eligible.

Not a fit: Patients who already have excellent glycemic control with current care, those unable or unwilling to attend participating centers or engage in education/peer activities, and individuals with pancreas or islet transplants are unlikely to gain additional benefit.

Why it matters

Potential benefit: If successful, this integrated approach could increase the proportion of people with type 1 diabetes who reach and maintain target blood glucose levels and reduce glycemic variability.

How similar studies have performed: Previous research shows that structured education, peer support, and diabetes technologies can each improve outcomes, but combining all four components in a single integrated program is less well tested.

Eligibility criteria

Inclusion Criteria:

1\. Patients with type 1 diabetes of all age groups, regardless of disease duration.

The diagnosis criteria for type 1 diabetes are met by fulfilling any one point from the first two criteria plus any one point from the third criterion.

1. Clinically diagnosed as Type 1 Diabetes by a specialist physician.
2. Meet any one of the following criteria:

   A. Age of onset \<15 years B. No obesity at the time of onset C. diabetic ketoacidosis onset D. Maximum random C-peptide \<200 pmol/L
3. Meet any one of the following criteria:

A. Initiation and continuation of insulin therapy after diagnosis (excluding pancreas or islet transplantation) B. Positive for islet cell antibodies

Where this trial is running

Beijing, Beijing Municipality and 9 other locations

• Department of Endocrinology and Metabolism, Peking University People's Hospital — Beijing, Beijing Municipality, China (Recruiting)
• Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University — Beijing, Beijing Municipality, China (Recruiting)
• Department of Endocrinology and Metabolism, the Third Affiliated Hospital of Sun Yat-sen University — Guangzhou, Guangdong, China (Recruiting)
• Department of Endocrinology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University — Shenzhen, Guangdong, China (Recruiting)
• Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology — Luoyang, Henan, China (Recruiting)
• Institute of Metabolism and Endocrinology, Second Xiangya Hospital of Centra South University — Changsha, Hunan, China (Recruiting)
• Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University — Nanjing, Jiangsu, China (Recruiting)
• Department of Endocrinology and Metabolism, Institute of Endocrinology, The First Affiliated Hospital of China Medical University — Shenyang, Liaoning, China (Recruiting)
• Department of Endocrinology and Metabolism, Laboratory of Diabetes and metabolism research, West China Hospital, Sichuan University — Chengdu, Sichuan, China (Recruiting)
• Department of Endocrinology, Children's Hospital of Zhejiang University School of Medicine, National Clinical Research Center for Child Health — Hangzhou, Zhejiang, China (Recruiting)

Study contacts

• Study coordinator: Xia Li

Conditions Type 1 Diabetes; Type 1 diabetes; Comprehensive management