Neurocognitive health in young kids with Type 1 diabetes and factors that help or hurt
Official title: Evaluating Neurocognitive Complications of Type 1 Diabetes (T1D) and Potential Risk and Protective Factors in Pre-Pubertal Children- New York University Clinical Center
Funded at New York University School of Medicine · NIH-11365794 · Data updated 2026-11-12
A study following young children with Type 1 diabetes to understand how the condition affects thinking skills and behavior, and what factors might protect or worsen these effects.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $600,860 |
| NIH project number | 5U01DK140791-03 |
| Project ID | NIH-11365794 on NIH RePORTER |
Who could benefit from this research
✓Could help
Prepubertal children with recently diagnosed Type 1 diabetes and demographically similar peers without diabetes.
✕Less likely to help
Children without diabetes or those not following the study protocol may not experience direct benefits.
What this research studies
This study enrolls prepubertal children with recently diagnosed Type 1 diabetes and compares them with similar children without diabetes to understand how dysglycemia and metabolic events influence brain development. It uses a harmonized protocol across centers to collect clinical data, neurocognitive assessments, and brain imaging over time. The NYU site coordinates with a central biostatistics center and specialized labs to examine a wide range of factors, including environment and health history, that could drive neurocognitive outcomes. The goal is to identify risk factors and protective factors so clinicians can tailor monitoring and interventions for young patients. Participation involves longitudinal follow-up at multiple sites with standardized testing and imaging.
Why it matters
Potential benefit: If successful, the study could reveal actionable factors to protect thinking skills and brain development in children with T1D.
How similar studies have gone: Previous research suggests neurocognitive effects exist, but this study aims for larger, longitudinal, harmonized data to clarify mechanisms.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Gallagher, Mary Patricia — New York University School of Medicine
- Study coordinator: Gallagher, Mary Patricia
Related research
Other NIH-funded projects on the same topics.
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Understanding brain changes in kids with new Type 1 diabetes
A multicenter study will follow young children with Type 1 diabetes and similar peers without diabetes to look for factors that influence brain development and thinking skills.
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Understanding Brain Changes in Children with Type 1 Diabetes
This research aims to understand how Type 1 Diabetes affects brain development and thinking skills in children.
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Brain Health in Young Children with Type 1 Diabetes
This project looks at how Type 1 Diabetes affects brain development and thinking skills in young children.
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Improving access to continuous glucose monitoring for children with type 1 diabetes.
This study is looking at how things like race and income affect whether kids with type 1 diabetes can use continuous glucose monitors (CGMs), and it aims to find ways to make sure all children have better access to this helpful technology for managing their diabetes.
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Investigating how type 1 diabetes affects brain development in young children
This study is looking at how type 1 diabetes affects the brain and thinking skills in young kids, and it’s inviting children with diabetes and those without to help us learn more by doing some fun brain tests and scans over a couple of years.
-
Understanding how Type 1 Diabetes affects brain development in children
This study is looking at how Type 1 Diabetes affects the thinking skills of young kids, exploring how things like high blood sugar can impact their brain development, so we can better understand and support children who might struggle with attention, learning, and memory.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.