Comparing how exercise affects blood sugar in adults with and without Type 1 diabetes.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized replicate crossover trial with two parallel phases: one for adults with Type 1 diabetes and one for healthy adults, each recruiting about 12 participants. After baseline testing (including body composition and VO2max), participants complete two test conditions (exercise on a cycle ergometer and rest) in randomized order and then repeat the same order the following week to measure reproducibility. Glucose is tracked continuously by CGM and intermittently by capillary blood sampling after a standardized breakfast, with at least 72 hours between test visits. The design compares within‑person repeatability and between‑person variability and also evaluates agreement between CGM and finger‑stick glucose values.

Why it matters

Who can join: the full rules

Inclusion Criteria:

(Healthy and T1D phases):

* age between 18 and 60 years old;
* being healthy individuals;
* engagement in physical activity at least once a week; (T1D phase):
* diagnosis of T1D for \>18 months;
* hypoglycaemia self awareness.

Exclusion Criteria:

(Healthy and T1D phases)

* presence of cardiovascular disease or contraindications to exercise;
* infectious or inflammatory conditions;
* chronic renal or liver disease;
* pregnancy;
* gestational diabetes;
* diagnosed eating disorders;
* any physical or mental condition preventing participation; (Healthy phase)
* diabetes mellitus (type 1 or type 2); (T1D phase)
* inability to self-manage diabetes.

Where it's running

• University College Dublin
  Dublin, Dublin, Ireland Recruiting

Study contacts

• Study coordinator: Veronica Merlo
• Email: veronica.merlo@ucdconnect.ie
• Phone: 3458479939

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.