TUBSIS 2.0 — an online program to help adults reduce or quit smoking and vaping

Effectiveness of an Internet-based, Self-help, Asynchronized Behavioral Therapy With Mindfulness Approach for Adults With Tobacco Smoking or Vaping to Support Adults in Reducing Tobacco Smoking and Vaping in Switzerland and Türkiye

This program tests whether a free, anonymous, 4-week web-based course using mindfulness, self-compassion, and behavior-change techniques helps German-, English-, and Turkish-speaking adults who smoke or vape reduce or quit tobacco.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 406 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: University of Zurich (other)
• Locations: 1 site (Zurich)
• Trial ID: NCT07568483 on ClinicalTrials.gov

What this trial studies

TUBSIS 2.0 is a fully remote, culturally adapted digital intervention that delivers eight structured modules over four weeks, integrating Health Action Process Approach principles with mindfulness and self-compassion exercises. Eligible adults are randomized to immediate access or a waitlist control and complete brief assessments at baseline, mid-intervention, post-intervention, and an eight-week follow-up. Primary outcomes include stage of behavior change, tobacco consumption patterns, and point-prevalence abstinence, with secondary outcomes such as mental well-being and nicotine dependence. The platform is anonymous, low-burden, and available in German, English, and Turkish.

Who should consider this trial

Good fit: Adults aged 18+ who currently smoke or vape (smoked on ≥1 day in the past 30 days or ≥100 lifetime cigarettes), have stable internet access, read German, English, or Turkish, and agree to randomization and follow-up assessments are ideal candidates.

Not a fit: People who prefer in-person medical care, require supervised pharmacotherapy or intensive cessation treatment, lack internet access or language proficiency, or are unwilling to be randomized may not benefit from this program.

Why it matters

Potential benefit: If successful, the program could increase quit or reduction rates and improve mental well-being while providing low-cost, anonymous support to people who face barriers to in-person services.

How similar studies have performed: Prior web-based and mindfulness-informed smoking cessation programs have shown modest success at increasing quit rates and well-being, but the multilingual, culturally adapted HAPA-plus-mindfulness combination and focus on vaping is less widely tested.

Eligibility criteria

Inclusion Criteria:

* Age: 18 years or older
* Smoking status:

Smoked on ≥1 day in the past 30 days, and/or Smoked at least 100 cigarettes in lifetime

* Internet access: Stable internet connection and access to a smartphone, tablet, or computer during interaction of the TUBSIS 2.0 web-based platform.
* Language: Sufficient reading and listening comprehension in the study language (German, English or Turkish)
* Contact: Valid email address and phone number (optional) for study communication, reminders and incentive payments
* Consent: Provided electronic informed consent on TUBSIS 2.0 web-based platform which is developed and administrated by ISGF.
* Study procedures: Agreement to randomization (intervention or control) and completion of study assessments at four time points (baseline, mid-intervention, post-intervention and 8-week follow-up)

Exclusion Criteria:

* Individuals who do not meet the inclusion criteria are excluded.

Where this trial is running

Zurich

• The Swiss Research Institute for Public Health and Addiction - ISGF (Schweizer Institut für Sucht- und Gesundheitsforschung) — Zurich, Switzerland (RECRUITING)

Study contacts

• Principal investigator: Michael Schaub, Prof. Dr. phil. — Swiss Research Institute for Public Health and Addiction - ISGF, University of Zurich
• Study coordinator: Michael Schaub, Prof. Dr. phil.

Conditions: Tobacco Use Disorder, Nicotine Dependence, Vaping, Smoking Tobacco, smoking tobacco, vaping, web-based intervention, mindfulness