A new method to help people with HIV quit smoking

A SMART Approach to Treating Tobacco Use Disorder in Persons Living with HIV

NIH-funded research Yale University · NIH-10893629

This study is looking at a new way to help people with HIV who want to quit smoking by trying different treatments based on how they respond, so if you're living with HIV and want to stop using tobacco, this research might be for you!

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionYale University NIH-funded
Lab location1 site (New Haven, United States)
Project IDNIH-10893629 on NIH RePORTER

What this research studies

This research investigates a novel approach to treating tobacco use disorder specifically in individuals living with HIV. It utilizes a Sequential Multiple Assignment Randomized Trial (SMART) design, which allows for dynamic treatment adjustments based on individual responses to initial therapies. Participants will be assigned to receive either nicotine replacement therapy alone or combined with contingency management, with follow-up assessments to tailor ongoing treatment. The goal is to improve long-term smoking cessation outcomes for this vulnerable population.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults over 21 years old who are living with HIV and currently smoke cigarettes.

Not a fit: Patients who do not smoke or are not living with HIV may not receive any benefit from this research.

Why it matters

Potential benefit: If successful, this research could significantly enhance smoking cessation rates among individuals living with HIV, improving their overall health and quality of life.

How similar studies have performed: Previous studies have shown modest success in short-term smoking cessation among individuals with HIV, but this SMART approach is relatively novel and aims to address long-term outcomes more effectively.

Where this research is happening

New Haven, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.