A new method to help people with HIV quit smoking
Official title: A SMART Approach to Treating Tobacco Use Disorder in Persons Living with HIV
Funded at Yale University · NIH-10893629 · Data updated 2026-11-12
This study is looking at a new way to help people with HIV who want to quit smoking by trying different treatments based on how they respond, so if you're living with HIV and want to stop using tobacco, this research might be for you!
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 19, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $178,206 |
| NIH project number | 5R01CA243910-06 |
| Project ID | NIH-10893629 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are living with HIV and currently smoke cigarettes.
✕Less likely to help
Patients who do not smoke or are not living with HIV may not receive any benefit from this research.
What this research studies
This research investigates a novel approach to treating tobacco use disorder specifically in individuals living with HIV. It utilizes a Sequential Multiple Assignment Randomized Trial (SMART) design, which allows for dynamic treatment adjustments based on individual responses to initial therapies. Participants will be assigned to receive either nicotine replacement therapy alone or combined with contingency management, with follow-up assessments to tailor ongoing treatment. The goal is to improve long-term smoking cessation outcomes for this vulnerable population.
Why it matters
Potential benefit: If successful, this research could significantly enhance smoking cessation rates among individuals living with HIV, improving their overall health and quality of life.
How similar studies have gone: Previous studies have shown modest success in short-term smoking cessation among individuals with HIV, but this SMART approach is relatively novel and aims to address long-term outcomes more effectively.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Edelman, E. Jennifer — Yale University
- Study coordinator: Edelman, E. Jennifer
Related research
Other NIH-funded projects on the same topics.
-
VR-based attentional bias as a biomarker for tobacco use disorder
A study at UC San Diego is testing a virtual reality task to see if attentional bias can serve as a biomarker to help treat cigarette addiction.
-
Community health worker support to help people with serious mental illness quit smoking
This project trains Medicaid behavioral health staff to act as community health workers who help adults with serious mental illness stop using tobacco.
-
Smoking-cessation meds with a team approach for people with HIV (SMARTTT)
A multi-site study tests a team-based plan using medication and rewards to help people with HIV quit smoking.
-
Using virtual reality to understand how attention affects tobacco addiction
This study is looking at how daily tobacco users react to virtual reality situations that remind them of smoking, to see if their attention to these cues can help predict how well they might do with quitting smoking, especially when using a medication called varenicline compared to a placebo.
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A program to help individuals with bipolar disorder reduce tobacco use through future thinking.
This study is testing a new program called 'Future Self-BD' to help people with bipolar disorder who want to quit smoking by imagining positive future outcomes from stopping, and it aims to see how well the program works and if it's easy to use.
-
Using focused ultrasound to help people quit smoking
This study is looking at a new, gentle ultrasound treatment that might help people who want to quit smoking by reducing their cravings for cigarettes, and it's designed for anyone struggling with tobacco use.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.