Condition

Surgical Site Infection clinical trials and research

• 27Clinical trials
• 16NIH research projects
• 1New in 30 days
• 20Countries

Newest Surgical Site Infection clinical trials

All recruiting trials (27)

• Silver foam dressing after cesarean: does it prevent infection as well as standard care?

  This trial tests whether a silver-containing foam dressing worn over cesarean incisions is no worse than standard dressings at preventing surgical site infections.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT07914569

• Skin staples vs polypropylene skin sutures after elective laparotomy

  This trial tests whether skin staples or polypropylene sutures work better for closing the skin after elective abdominal surgery in adults.

  Recruiting Pakistan Institute of Medical Sciences · Islamabad, Capital · NCT07781878

• Hernia Sac Flap Coverage of Mesh in Complex Bony-Edged Ventral Hernias

  We’re testing whether using the patient’s own hernia sac as a living flap underneath the mesh helps healing after complex ventral hernia repair when part of the edge is bone.

  Recruiting Minia University · Minya, Minya Governorate · NCT07720154

• Steri-Strips added to standard wound closure after cesarean delivery

  This study tests whether adding Steri-Strips after a C-section helps reduce wound problems for pregnant patients.

  Recruiting Riverside University Health System Medical Center · Moreno Valley, California · NCT07686913

• Cold atmospheric plasma to improve cannulation-site wound healing after extracorporeal life support

  This trial will test whether adding cold atmospheric plasma (CAP) to standard wound care helps adults on extracorporeal life support heal cannulation-site wounds faster and with fewer infections.

  Recruiting National Taiwan University Hospital · Taipei · NCT07501897

• Preventing wound infections in children having open groin surgery with IV antibiotics or antimicrobial-coated sutures

  This will test whether a single IV antibiotic dose or antimicrobial-coated sutures prevent wound infections in children having open groin surgery.

  Recruiting Obafemi Awolowo University Teaching Hospital · Ile-Ife, Osun State · NCT07346742

• Local subcutaneous gentamicin to prevent surgical site infections after elective cesarean section

  This trial tests whether injecting a small dose of gentamicin under the skin at the incision lowers the chance of surgical site infection after an elective cesarean delivery.

  Recruiting Western Galilee Hospital-Nahariya · Nahariya · NCT07311395

• AI detection of deep surgical site infections after elective colorectal surgery

  It will test an AI algorithm that scans medical records to find surgical site infections in people who have planned colorectal surgery.

  Recruiting Hospital de Granollers · Granollers, Barcelona · NCT07130656

• Negative pressure dressings after emergency midline laparotomy

  This trial will test whether using negative pressure wound therapy on adults having emergency midline laparotomy lowers wound complications compared with standard dressings.

  Recruiting at 5 sites Uppsala University · Eskilstuna and 5 other locations · NCT07003906

• Comparing chlorhexidine and saline for cleaning during colorectal cancer surgery

  This study is testing whether using chlorhexidine instead of saline to clean the surgical area during colorectal cancer surgery can help reduce infections and complications for patients aged 18-85 with resectable tumors.

  Recruiting Nanchong Central Hospital · Nanchong, Sichuan · NCT06869096

• Xperience™ versus dilute povidone-iodine to prevent infections after implant-based breast reconstruction

  This trial will test whether Xperience™ surgical irrigation reduces infection and complication rates compared with dilute povidone-iodine in women 18 and older having implant-based breast reconstruction after mastectomy.

  Recruiting University of North Carolina, Chapel Hill · Chapel Hill, North Carolina · NCT06649890

• Comparing insulin regimens to reduce surgical site infections in diabetes patients

  This study is testing if a new way of giving insulin can help reduce the risk of infections after surgery for people with type 2 diabetes.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Amsterdam · NCT06638567

• ChatGPT-4 to detect surgical wound infections after colorectal surgery

  We will test whether ChatGPT-4 can accurately find surgical site infections from electronic health records in people having elective colorectal resection.

  Recruiting Hospital de Granollers · Granollers, Barcelona · NCT06626399

• Antiseptic washing during cesarean section

  This study tests if washing the skin before closing up after a cesarean section can help prevent infections and improve recovery for new moms.

  Recruiting Hadassah Medical Organization · Jerusalem · NCT06454227

• Using Irrisept Solution to Prevent Infections After Spine Surgery

  This study is testing if using Irrisept instead of regular saline can help prevent infections after spine surgery for adults with different spinal conditions.

  Recruiting Rhode Island Hospital · Providence, Rhode Island · NCT06439953

• Comparing diluted povidone-iodine and saline to reduce surgical site infections

  This study is testing whether using diluted povidone-iodine instead of saline during surgery can help prevent infections in patients having emergency abdominal surgery.

  Recruiting Phase 3 Loma Linda University · Loma Linda, California · NCT06363877

• Comparing two methods for closing ostomy wounds

  This study is testing two different ways to close ostomy wounds to see which method helps patients heal better and feel good about their recovery.

  Recruiting Phase 4 University of Nevada, Las Vegas · Las Vegas, Nevada · NCT06309368

• Comparing Povidone-iodine and Saline for Preventing Infections in Colorectal Surgery

  This study is testing whether using povidone-iodine or saline to clean surgical cuts can help prevent infections in patients having colorectal surgery.

  Recruiting Phase 3 Hospital de Clinicas de Porto Alegre · Porto Alegre, Rio Grande do Sul · NCT06302335

• Comparing disposable and reusable surgical drapes and gowns to reduce infections

  This study is testing if reusable surgical drapes and gowns can help prevent infections just as well as disposable ones for patients having surgery.

  Recruiting University of Birmingham · Guadalajara · NCT06164444

• Comparing saline irrigation and povidone-iodine for preventing infections in emergency surgeries

  This study is testing whether using saline irrigation or a povidone-iodine solution before closing surgical incisions can better prevent infections in patients having emergency surgeries.

  Recruiting Phase 2/3 Dow University of Health Sciences · Karachi, Sindh · NCT05989386

• Comparing two types of sutures for closing surgical wounds

  This study is testing whether a special coated suture can help prevent infections better than a regular suture in patients having surgery.

  Recruiting at 4 sites Aesculap AG · Naples and 3 other locations · NCT05966961

• Reducing surgical site infections after colon or small bowel surgery

  This study is testing whether using special washes and ointments can help prevent infections after colon or small bowel surgery for patients who have just been discharged from the hospital.

  Recruiting at 4 sites Phase 4 University of California, Irvine · Newport Beach, California and 3 other locations · NCT05586776

• Using broad-spectrum antibiotics to prevent infections in orthopedic surgery

  This study tests whether using a stronger type of antibiotics before orthopedic surgery can help prevent infections in patients who are at high risk.

  Recruiting Phase 3 Balgrist University Hospital · Zurich · NCT05502380

• Comparing durations of antibiotic use after cardiac surgery

  This study is testing how long to give antibiotics after heart surgery to see which duration best prevents infections.

  Recruiting at 21 sites Phase 4 Monash University · Dallas, Texas and 26 other locations · NCT05447559

• Evaluating the effects of showering on postoperative complications with drains

  This study is testing if showering with drains after breast reduction or panniculectomy surgery affects the risk of complications for patients.

  Recruiting Geisinger Clinic · Danville, Pennsylvania · NCT04725916

• Improving respiratory care for patients having high-risk abdominal surgery

  This study is testing whether using a special mouthwash and different amounts of oxygen before surgery can help reduce the chances of pneumonia and infections in patients having major abdominal surgery.

  Recruiting at 34 sites Phase 3 University of Birmingham · Botucatu, São Paulo and 36 other locations · NCT04256798

• Comparing zinc oxide and petrolatum for healing surgical scars

  This study is testing whether zinc oxide ointment works better than petrolatum for healing and reducing scars after skin surgery.

  Recruiting Early Phase 1 University of Pittsburgh · Pittsburgh, PA, Pennsylvania · NCT03561376

NIH-funded research (16)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Integrated microbiome and resistome framework to prevent surgical site infections in veterinary orthopedic surgery

  A veterinary research project will study how preoperative microbes and resistance genes in animals relate to post-surgical infections and antibiotic failures.

  NIH research Kansas State University · Manhattan, United States · NIH-11529102

• Image-based tools to spot post-cesarean wound infections across different populations

  Aims to test two image-based computer algorithms to detect infections after cesarean birth, using real patient images from diverse sites to help earlier care.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11478410

• Image-based tools to spot post-cesarean wound infections early

  Aims to use pictures and thermal images to help clinicians and community health workers detect cesarean-site infections sooner in women in Africa and Latin America.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11478409

• Targeting the preoperative microbiome to prevent surgical infections and antibiotic resistance

  Aims to understand how a patient’s microbiome before surgery influences the risk of infection and antibiotic resistance, with the goal of preventing surgical site infections.

  NIH research University of Washington · Seattle, United States · NIH-11427104

• Decolonization to prevent infections after colon and small bowel surgery

  A clinical trial will test whether a post-discharge cleaning regimen (chlorhexidine baths and nasal antiseptic) reduces infections after colon and small bowel surgery.

  NIH research University of California-Irvine · Irvine, United States · NIH-11421131

• Image-based tools to detect cesarean wound infections from photos and heat images in diverse women

  A patient-friendly way to use photos and thermal images to detect cesarean wound infections early, helping mothers in various countries get timely care.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11402719

• Remote photo and thermal checks to spot cesarean wound infections

  This project uses photos and thermal images to help healthcare workers detect wound infections after cesarean delivery in women from Rwanda, Ghana, and Mexico.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11397943

• Remote photo and thermal imaging to detect C-section wound infections

  Uses photo and thermal imaging tools to detect wound infections after C-section among women in Rwanda, Ghana, and Mexico.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11397942

• Photos and thermal scans to spot wound infections after cesarean births

  This project will use smartphone photos and thermal images to help community health workers find wound infections after cesarean delivery in women in Rwanda, Ghana, and Mexico.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11394211

• Understanding how the patient microbiome affects infections after spine surgery

  This study is looking at how the bacteria in your body might affect the chances of getting an infection after spine surgery, and it’s for patients who are having procedures like spinal fusion to help find better ways to prevent these infections.

  NIH research University of Washington · Seattle, United States · NIH-11299862

• Investigating how the immune system affects antibiotic use in preventing surgical site infections

  This study is looking at how the immune system and antibiotics work together to prevent infections after surgery, especially for patients with weakened immune systems, to find better ways to keep everyone safe and healthy during recovery.

  NIH research University of California at Davis · Davis, United States · NIH-11142260

• Preventing wound infections after open colon and small bowel surgery

  This trial tests whether doing chlorhexidine body washes and using a nasal iodophor after you leave the hospital can reduce wound infections in people who had open colon or small bowel surgery.

  NIH research University of California-Irvine · Irvine, United States · NIH-11093397

• Understanding infections after oral cancer surgery

  This study is looking into why some people get infections after surgery for oral cancer, especially those who have surgery to rebuild their mouths, and it aims to find ways to prevent these infections so patients can heal better.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11077814

• Understanding how the patient microbiome affects infections after spine surgery

  This study is looking at how the bacteria in your body might affect the risk of getting infections after spine surgery, and it aims to find ways to prevent these infections to help you heal better.

  NIH research University of Washington · Seattle, United States · NIH-11010419

• Keeping surgical antibiotic use correct after reporting ends

  This project checks whether correct antibiotic timing before surgery continued for Veterans after a mandatory hospital reporting program ended.

  NIH research VA Boston Health Care System · Boston, United States · NIH-11005693

• Improving prevention of surgical site infections using personalized medicine.

  This study is looking at how to better prevent infections after colorectal surgery for people with obesity by using medical scans to give the right amount of antibiotics based on each person's body type, so they can heal better and avoid extra hospital costs.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10689740

Related topics

Quick answers

How many Surgical Site Infection clinical trials are recruiting right now?

27, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in United States (10 trials), Spain (3 trials), Israel (2 trials), Pakistan (2 trials), Brazil (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 4, Phase 4: 3, Phase 2/3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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