Integrated microbiome and resistome framework to prevent surgical site infections in veterinary orthopedic surgery
Official title: Development of an Integrated Microbiome-Resistome Surveillance Framework for Antimicrobial Resistance and Surgical Site Infection in Veterinary Orthopedic Surgery
Funded at Kansas State University · NIH-11529102 · Data updated 2026-11-12
A veterinary research project will study how preoperative microbes and resistance genes in animals relate to post-surgical infections and antibiotic failures.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Kansas State University NIH-funded |
| Lab location | 1 site (Manhattan, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $134,469 |
| NIH project number | 1U18FD008933-01 |
| Project ID | NIH-11529102 on NIH RePORTER |
Who could benefit from this research
✓Could help
Veterinary patients undergoing orthopedic surgery at participating sites, with samples collected as part of standard care.
✕Less likely to help
Animals whose surgery and sample collection do not yield informative microbiome or resistome data may receive no direct benefit.
What this research studies
This project will map the bacteria and resistance genes present in animals before orthopedic surgery and compare them to those found in infections after surgery. Researchers will use genomic and microbiome analyses to see if preoperative strains match SSI pathogens and to build AMR surveillance workflows. They will also examine how the preoperative resistome relates to prophylaxis-resistant infections and compare strains from infected wounds to healthy surgical wounds to identify virulence and genomic differences. The goal is to develop prevention strategies that reduce SSIs and improve antibiotic stewardship in veterinary patients.
Why it matters
Potential benefit: If successful, the approach could reduce surgical infections in animals and guide better antibiotic use.
How similar studies have gone: Similar microbiome and resistome studies have shown potential in understanding infections, but this integrated approach in veterinary surgery is relatively novel.
Where this research is happening
-
Kansas State University
Manhattan, United States Active
Researchers
- Principal investigator: Hanzlicek, Gregg a — Kansas State University
- Study coordinator: Hanzlicek, Gregg a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.