Comparing durations of antibiotic use after cardiac surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicentre, adaptive, double-blind, three-arm, placebo-controlled, randomised clinical trial aims to evaluate the effectiveness of different durations of intravenous cefazolin prophylaxis in preventing surgical site infections (SSI) in patients undergoing cardiac surgery. Participants will be assigned to one of three groups: receiving prophylaxis only during surgery, for 24 hours post-surgery, or for 48 hours post-surgery. The study will assess the incidence of SSI, healthcare-associated infections, and the economic and microbiological impacts of these different prophylaxis durations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- Adult patients undergoing cardiac surgery involving a median sternotomy

Exclusion Criteria:

* Age \<18 years
* American Society of Anesthesiology (ASA) 5
* Subjects with GFR \<40mL/min/1.73m2 or those requiring continuous renal replacement therapy, haemodialysis or peritoneal dialysis
* Surgery for suspected or proven endocarditis or deep sternal wound infection
* Documented cefazolin hypersensitivity
* Documented methicillin resistant Staphylococcus aureus (MRSA) colonisation or infection in the 12-months prior to index surgery
* Cardiac transplantation
* Procedures involving insertion ventricular assist device or mechanical circulatory support device
* Procedures not involving a median sternotomy
* Patients previously enrolled and randomised to the CALIPSO trial

Where it's running

• Westmead Hospital
  Sydney, New South Wales, Australia Recruiting
• The Prince Charles Hospital
  Brisbane, Queensland, Australia Recruiting
• Princess Alexandra Hospital
  Brisbane, Queensland, Australia Recruiting
• Royal Adelaide Hospital
  Adelaide, South Australia, Australia Recruiting
• Flinders Medical Centre
  Adelaide, South Australia, Australia Recruiting
• Flinders Private
  Adelaide, South Australia, Australia Recruiting

Study contacts

• Principal investigator: Trisha Peel, MBBS GradCertRes FRACP PhD — Monash University
• Study coordinator: Paige Druce, MSc(Epi)
• Email: paige.druce@monash.edu
• Phone: 9903 0016

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Silver foam dressing after cesarean: does it prevent infection as well as standard care?

  This trial tests whether a silver-containing foam dressing worn over cesarean incisions is no worse than standard dressings at preventing surgical site infections.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT07914569

• Skin staples vs polypropylene skin sutures after elective laparotomy

  This trial tests whether skin staples or polypropylene sutures work better for closing the skin after elective abdominal surgery in adults.

  Recruiting Pakistan Institute of Medical Sciences · Islamabad, Capital · NCT07781878

• Hernia Sac Flap Coverage of Mesh in Complex Bony-Edged Ventral Hernias

  We’re testing whether using the patient’s own hernia sac as a living flap underneath the mesh helps healing after complex ventral hernia repair when part of the edge is bone.

  Recruiting Minia University · Minya, Minya Governorate · NCT07720154

• Steri-Strips added to standard wound closure after cesarean delivery

  This study tests whether adding Steri-Strips after a C-section helps reduce wound problems for pregnant patients.

  Recruiting Riverside University Health System Medical Center · Moreno Valley, California · NCT07686913

• Cold atmospheric plasma to improve cannulation-site wound healing after extracorporeal life support

  This trial will test whether adding cold atmospheric plasma (CAP) to standard wound care helps adults on extracorporeal life support heal cannulation-site wounds faster and with fewer infections.

  Recruiting National Taiwan University Hospital · Taipei · NCT07501897

• Preventing wound infections in children having open groin surgery with IV antibiotics or antimicrobial-coated sutures

  This will test whether a single IV antibiotic dose or antimicrobial-coated sutures prevent wound infections in children having open groin surgery.

  Recruiting Obafemi Awolowo University Teaching Hospital · Ile-Ife, Osun State · NCT07346742

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.