Comparing saline irrigation and povidone-iodine for preventing infections in emergency surgeries
Outcomes of High-volume Saline Irrigation VS Povidone-Iodine Solution Cleaning of Intraoperative Incision Wound in Preventing Surgical Site Infections in Emergency Laparotomies: A Randomized Controlled Trial
This study is testing whether using saline irrigation or a povidone-iodine solution before closing surgical incisions can better prevent infections in patients having emergency surgeries.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Dow University of Health Sciences Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Trial ID | NCT05989386 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the effectiveness of high-volume saline irrigation versus povidone-iodine solution in preventing superficial surgical site infections (SSIs) in patients undergoing emergency laparotomies. Participants will be randomly assigned to receive either saline irrigation or conventional closure without irrigation before their incisions are closed. The study will measure the incidence of SSIs and the length of hospital stays following the interventions. By comparing these two methods, the trial seeks to identify the more effective approach for reducing infection rates in surgical settings.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-60 undergoing emergency laparotomy at the specified hospital.
Not a fit: Patients with diabetes, immune suppression, or recent abdominal surgeries will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved infection prevention strategies in emergency surgeries, enhancing patient outcomes.
How similar studies have performed: Previous studies have shown varying success with similar approaches, but this specific comparison is novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Patients undergoing emergency laparotomy under the care of surgical-6 unit of Dr. Ruth K. M. Pfau Civil Hospital Karachi * The age of patients should be between 18-60 years old. Exclusion Criteria: * Diabetic patients * Immune-suppressed patients * Patients taking steroids * Patients undergoing chemo-radiotherapy. * Pregnant females * Previous abdominal surgery within the last 30 days. * Presence of concurrent abdominal wall infections. * Trauma Laparotomies * Large Bowel perforations
Where this trial is running
Karachi, Sindh
- Dr. Ruth K. M. Pfau Civil Hospital Karachi — Karachi, Sindh, Pakistan (Recruiting)
Study contacts
- Principal investigator: Omer Bin Khalid, Assist Prof. — Dr. Ruth F. M. Pfau Civil Hospital Karachi
- Study coordinator: Omer Bin Khalid, Assist Prof.
- Email: dromerkhalid@gmail.com
- Phone: +92 321 2040064
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.