Comparing diluted povidone-iodine and saline to reduce surgical site infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter randomized controlled trial aims to evaluate the effectiveness of diluted aqueous povidone-iodine compared to normal saline for intraoperative wound irrigation and peritoneal lavage in patients undergoing emergency laparotomies. The study will enroll 1100 patients aged 18 to 80 with CDC class 2 and 3 wounds, assessing both the reduction of surgical site infections and the safety of the povidone-iodine solution. Participants will be followed for 18 months, with evaluations up to 30 days post-surgery to monitor outcomes and any adverse events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 to 80 years of age
* undergoing an exploratory laparotomy for Centers for Disease Control class II and III wounds

Exclusion Criteria:

* Pregnancy
* Preoperative abdominal wall skin/soft tissue infection
* Iodine allergy
* Patients unlikely to survive beyond 30 days
* Patients with mesh placement or placement of a foreign body except for drains

Where it's running

• Loma Linda University Health
  Loma Linda, California, United States Recruiting

Study contacts

• Study coordinator: Martin G Rosenthal, MD
• Email: mrosenthal@ll.edu
• Phone: 909-558-4000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.