Investigating how the immune system affects antibiotic use in preventing surgical site infections
Official title: Role of immune system in prophylaxis antibiotic's surgical site infection control
Funded at University of California at Davis · NIH-11142260 · Data updated 2026-11-12
This study is looking at how the immune system and antibiotics work together to prevent infections after surgery, especially for patients with weakened immune systems, to find better ways to keep everyone safe and healthy during recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | September 23, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $402,500 |
| NIH project number | 7R01AI150668-05 |
| Project ID | NIH-11142260 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients undergoing surgical procedures, especially those who are immunocompromised.
✕Less likely to help
Patients who are not undergoing surgery or those with stable immune systems may not benefit from this research.
What this research studies
This research explores the relationship between the immune system and the effectiveness of prophylactic antibiotics in preventing surgical site infections (SSIs). It aims to understand whether the immune system can enhance the effectiveness of these antibiotics or if the antibiotics can boost immune function. The study will involve examining patients undergoing surgery, particularly focusing on those who are immunocompromised, to identify novel, potentially antibiotic-free approaches to infection control. By analyzing the immune response and antibiotic interactions, the research seeks to improve surgical outcomes and reduce the incidence of SSIs.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing surgical site infections, particularly in vulnerable patient populations.
How similar studies have gone: While the role of the immune system in antibiotic effectiveness is a relatively novel area of investigation, there have been some preliminary studies suggesting that immune modulation could enhance infection control.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Shafikhani, Sasha H — University of California at Davis
- Study coordinator: Shafikhani, Sasha H
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.