Improving prevention of surgical site infections using personalized medicine.
Official title: Precision Prophylaxis of Surgical Site Infection Utilizing Pharmacomorphomics
Funded at University of Michigan at Ann Arbor · NIH-10689740 · Data updated 2026-11-12
This study is looking at how to better prevent infections after colorectal surgery for people with obesity by using medical scans to give the right amount of antibiotics based on each person's body type, so they can heal better and avoid extra hospital costs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2019 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $467,204 |
| NIH project number | 5R01HS027183-05 |
| Project ID | NIH-10689740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients undergoing colorectal surgery who are classified as obese or morbidly obese.
✕Less likely to help
Patients who are not undergoing surgical procedures or those with normal body weight may not benefit from this research.
What this research studies
This research focuses on reducing the risk of surgical site infections (SSI) in patients undergoing colorectal surgery, particularly those with obesity. By analyzing medical imaging scans, the study aims to tailor antibiotic prophylaxis based on individual body composition, ensuring that patients receive the appropriate dosage for effective infection prevention. The approach seeks to address the current limitations in antibiotic dosing guidelines, which do not adequately consider the unique needs of obese patients. Through this personalized method, the research hopes to enhance patient outcomes and reduce healthcare costs associated with SSIs.
Why it matters
Potential benefit: If successful, this research could significantly lower the incidence of surgical site infections, leading to better recovery outcomes and reduced healthcare costs for patients.
How similar studies have gone: Previous studies have indicated that personalized approaches to antibiotic dosing can improve treatment outcomes, suggesting a promising avenue for this research.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Wang, Stewart C — University of Michigan at Ann Arbor
- Study coordinator: Wang, Stewart C
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.