Cold atmospheric plasma to improve cannulation-site wound healing after extracorporeal life support

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, controlled trial enrolling adults on extracorporeal life support (ECLS) who have cannulation-site wounds. Participants are randomized 1:1 to receive standard wound care alone or standard care plus topical cold atmospheric plasma (CAP) applied at predefined intervals using a medical device. Outcomes include quantitative bacterial burden (fluorescence imaging and cultures), cytokine analysis of wound exudate, clinical wound-healing scores, wound surface measurements, time to epithelialization, need for surgical debridement, infection incidence, and safety monitoring. The study aims to determine whether CAP reduces biofilm and inflammation and accelerates healing in this high-risk population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Receiving extracorporeal life support (ECLS)
* Presence of cannulation site wound requiring wound care

Exclusion Criteria:

* Pre-existing severe dermatological conditions at the cannulation site
* Severe coagulopathy precluding local intervention
* Concurrent receipt of other experimental wound treatments
* Life expectancy \< 48 hours

Where it's running

• National Taiwan University Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Study coordinator: Chih-Yang Chan
• Email: chanchihyang@gmail.com
• Phone: +886-975810806

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.