Investigating imaging techniques for diagnosing non-convulsive status epilepticus
The Role of Cerebral Functional, Structural and Spectral Imaging in the Diagnosis, Management and Prognosis of Status Epilepticus: a Prospective Study in Patients with the Ictal-interictal Continuum
This study is testing three different imaging techniques to see which one best helps doctors diagnose non-convulsive status epilepticus in patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven) |
| Trial ID | NCT06017973 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of three imaging techniques—FDG-PET, perfusion MRI, and CT perfusion—in diagnosing possible non-convulsive status epilepticus (NCSE). It will involve 180 patients with NCSE and 20 control subjects, focusing on identifying brain hypermetabolism and hyperperfusion as indicators of the condition. The study will also analyze EEG patterns associated with these imaging findings and assess the management and outcomes of patients based on their imaging results.
Who should consider this trial
Good fit: Ideal candidates include patients exhibiting possible non-convulsive status epilepticus with specific EEG patterns.
Not a fit: Patients with contraindications for MRI or those who cannot tolerate imaging procedures may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and management strategies for patients with non-convulsive status epilepticus.
How similar studies have performed: While there have been studies on imaging techniques for epilepsy, this specific approach focusing on NCSE is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: \- The patient has possible non-convulsive status epilepticus with scalp or invasive EEG with ictal-interictal continuum patterns on EEG Exclusion Criteria: * The patient has a contra-indication for MRI such as metal implants * The patient has contrast sensitivity * The patiensuffers from claustrophobia or cannot tolerate confinement during PET-MRI scanning procedures
Where this trial is running
Leuven
- University Hospitals Leuven, department of Neurology — Leuven, Belgium (Recruiting)
Study contacts
- Principal investigator: Wim Van Paesschen, MD PhD — UZ Leuven
- Study coordinator: Wim Van Paesschen, MD PhD
- Email: Wim.vanpaesschen@kuleuven.be
- Phone: +3216344332
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.