Understanding the causes of severe epilepsy and autoimmune encephalitis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study collects blood, cerebrospinal fluid, and post-mortem tissues from patients with status epilepticus or epilepsy linked to dysimmune encephalitis, as well as control patients. The goal is to explore the pathophysiology of these severe epileptic disorders and identify new therapeutic strategies. By analyzing biological samples and clinical data, the study aims to uncover mechanisms that trigger epileptogenesis and the role of autoimmunity in these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Group 1:

* Patients aged 2 years or above, with status epilepticus.
* Affiliation to a French social security system excluding "Aide Médicale" Etat (AME).
* Patients or relatives have been informed and given free informed and written consent to participate
* Patients under legal protection (guardianship, curatorship) or not

Group 2:

* Patients aged 2 years or above, with clinical signs of epilepsy associated to dysimmune encephalitis.
* Affiliation to a French social security system excluding "Aide Médicale" Etat (AME).
* Patients or relatives have been informed and given free informed and written consent to participate
* Patients under legal protection (guardianship, curatorship) or not

Group 3:

* Patients aged 18 years or above, without status epilepticus and/or dysimmune encephalitis.
* Affiliation to a French social security system excluding "Aide Médicale" Etat (AME).
* Patients or relatives have been informed and given free informed and written consent to participate
* Patients under legal protection (guardianship, curatorship) or not

Exclusion Criteria:

Group 1:

* Women with known or clinically detected pregnancy.
* Patient deprived of liberty
* Patients with known neurodegenerative disease.

Group 2:

* Women with known or clinically detected pregnancy.
* Patient deprived of liberty
* Patients have been already treated by corticoids or IgIV.

Group 3:

* Women with known or clinically detected pregnancy.
* Patient deprived of liberty.
* Patients with status epilepticus.
* Patients with known neurodegenerative disease, brain tumor, severe head trauma, meningitis, subarachnoid hemorrhages, stroke.

Where it's running

• Hôpital de la Pitié Salpêtrière
  Paris, France Recruiting

Study contacts

• Principal investigator: Vincent NAVARRO, Pr — Hôpital Pitié Salpêtrière - Assitance Publique Hôpitaux de Paris
• Study coordinator: Vincent NAVARRO, Pr
• Email: vincent.navarro@aphp.fr
• Phone: 01 42 16 19 40

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.