Faster treatment for status epilepticus in children
Official title: Quality Improvement in time to Treatment of Status Epilepticus (QuITT-SE)
Funded at Research Inst Nationwide Children's Hosp · NIH-11195136 · Data updated 2026-11-12
Hospitals will use a standard set of care changes to help children (infants through 11 years) get faster treatment for prolonged seizures to lower the chance of brain injury and complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $626,761 |
| NIH project number | 5R01NS133037-03 |
| Project ID | NIH-11195136 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children from birth through about 11 years who experience acute prolonged seizures or status epilepticus and receive emergency or inpatient care at participating pediatric hospitals.
✕Less likely to help
Children whose care occurs outside participating hospitals or whose seizures stop quickly without needing emergency benzodiazepines are unlikely to be affected by this project.
What this research studies
This project rolls out a package of proven hospital care changes across many pediatric hospitals with different locations and patient populations. The interventions were developed at one center and previously doubled the number of seizures treated within recommended times while cutting complications and costs. Participating hospitals will change workflows and track how quickly benzodiazepines are given, seizure outcomes, and related health care use. The study uses a stepped implementation approach so hospitals adopt the changes in phases while researchers collect data from medical records and care teams.
Why it matters
Potential benefit: If successful, children with prolonged seizures could get faster, correctly dosed treatment, reducing the risk of permanent brain injury, death, and long hospital stays.
How similar studies have gone: A prior single-center quality improvement effort using these same interventions doubled on-time treatment, reduced morbidity, and saved substantial hospital charges, but this is the first large multicenter rollout.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Ostendorf, Adam P. — Research Inst Nationwide Children's Hosp
- Study coordinator: Ostendorf, Adam P.
Related research
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ARISEN Network: Patient-centered outcomes in autoimmune brain inflammation and status epilepticus
A nationwide registry study from Emory will collect patient- and caregiver-reported outcomes to understand how neuroinflammatory brain diseases affect people and what helps them most.
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ARISEN: A regional network to understand autoimmune brain diseases in kids
A national, multi-center effort follows children with autoimmune brain diseases to better understand how their condition progresses and how it affects thinking and everyday life.
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ARISEN: Advancing research on autoimmune brain diseases and neuroinflammation
This grant supports a Career Enhancement Core to train the next generation of clinician-scientists studying autoimmune brain diseases like autoimmune encephalitis, Rasmussen’s syndrome, and NORSE, with a focus on pediatric cases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.