Faster treatment for status epilepticus in children
Quality Improvement in time to Treatment of Status Epilepticus (QuITT-SE)
Hospitals will use a standard set of care changes to help children (infants through 11 years) get faster treatment for prolonged seizures to lower the chance of brain injury and complications.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-11195136 on NIH RePORTER |
What this research studies
This project rolls out a package of proven hospital care changes across many pediatric hospitals with different locations and patient populations. The interventions were developed at one center and previously doubled the number of seizures treated within recommended times while cutting complications and costs. Participating hospitals will change workflows and track how quickly benzodiazepines are given, seizure outcomes, and related health care use. The study uses a stepped implementation approach so hospitals adopt the changes in phases while researchers collect data from medical records and care teams.
Who could benefit from this research
Good fit: Children from birth through about 11 years who experience acute prolonged seizures or status epilepticus and receive emergency or inpatient care at participating pediatric hospitals.
Not a fit: Children whose care occurs outside participating hospitals or whose seizures stop quickly without needing emergency benzodiazepines are unlikely to be affected by this project.
Why it matters
Potential benefit: If successful, children with prolonged seizures could get faster, correctly dosed treatment, reducing the risk of permanent brain injury, death, and long hospital stays.
How similar studies have performed: A prior single-center quality improvement effort using these same interventions doubled on-time treatment, reduced morbidity, and saved substantial hospital charges, but this is the first large multicenter rollout.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Ostendorf, Adam P. — Research Inst Nationwide Children's Hosp
- Study coordinator: Ostendorf, Adam P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.