Augmented kidney clearance in neurocritical care
Official title: Augmented Renal Clearance in Neurocritical Care Population: A Prospective Multicenter Study
Run by University of Alberta · NCT07410624 · Data updated 2026-11-12
This project will test whether adults in the neuro-ICU with severe brain injury, stroke, seizures, or brain infections have faster kidney clearance (ARC) that can lower antiseizure and antibiotic drug levels.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 85 Years |
| Sex | All |
| Enrollment | 512 (estimated) |
| Sponsor | University of Alberta Academic / other |
| Locations | 3 sites (Lexington, Kentucky and 2 other locations) |
| Status | Recruiting |
| Started | October 1, 2021 |
| Main results expected | September 30, 2026 |
| Study ends | September 30, 2026 |
| Registry record updated | February 18, 2026 |
| Trial ID | NCT07410624 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–85 admitted to a participating ICU with SAH, TBI, ICH, meningitis, status epilepticus or ischemic stroke who have a Foley catheter in place are ideal candidates.
✕Probably not a fit
Patients with anticipated ICU stays under 72 hours, those without a Foley catheter, incarcerated individuals, or patients with established low kidney function are unlikely to benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Severe brain injuries, strokes, status epilepticus and meningitis are often complicated by augmented renal clearance (ARC), where the kidneys clear drugs faster than expected. This multicenter observational study will enroll adults in participating neurocritical care ICUs and use timed urine collections (via Foley catheter) and blood sampling to measure creatinine clearance and drug exposures. Measured creatinine clearance (with ARC defined as CrCl >130 ml/min/1.73 m2) will be compared to common estimated equations while antiseizure and antimicrobial dosing and clinical outcomes are recorded. The overall aim is to characterize how common ARC is in these neurocritical populations and to generate guidance for clinicians on identification and monitoring.
Why it matters
Potential benefit: If successful, the results could help clinicians detect ARC and adjust drug doses to avoid under-treatment of seizures and infections.
How similar studies have gone: Prior studies outside neurocritical care have shown ARC can reduce concentrations of renally cleared drugs, but ARC in neurocritical care patients remains under-studied and lacks clear dosing recommendations.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18-85 years 2. Admitted to ICU at one of the participating sites 3. Diagnosis: SAH, TBI, ICH, meningitis, SE or ischemic stroke 4. Provision of informed consent 5. Foley catheter in place at time of consent (to facilitate urine collection) Exclusion Criteria: 1. Incarceration 2. Anticipated ICU length of stay is \< 72 hours (insufficient time for monitoring)
Where it's running
-
UK HealthCare
Lexington, Kentucky, United States Recruiting -
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States Recruiting -
University of Alberta Hospital
Edmonton, Alberta, Canada Recruiting
Study contacts
- Principal investigator: Sherif H Mahmoud, BSc (Pharm), MSc, PhD, FNCS — University of Alberta
- Study coordinator: Sherif H Mahmoud, BSc (Pharm), MSc, PhD, FNCS
- Email: smahmoud@ualberta.ca
- Phone: 780.492.5364
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.