Quality improvements to speed up treatment for pediatric status epilepticus
Official title: Quality Improvement in time to Treatment of Status Epilepticus (QuITT-SE)
Funded at Research Inst Nationwide Children's Hosp · NIH-11393365 · Data updated 2026-11-12
A national study tests a set of quick, standardized steps to treat pediatric seizures faster and reduce brain injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $639,809 |
| NIH project number | 5R01NS133037-04 |
| Project ID | NIH-11393365 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with acute seizures who are at risk of progressing to status epilepticus at participating pediatric hospitals.
✕Less likely to help
Children not experiencing seizures or not treated at participating centers may not benefit.
What this research studies
This project works with several children’s hospitals to apply proven timing-based care steps for status epilepticus and see how fast treatment can be delivered in real life. It builds on a successful initial study that doubled timely treatment and reduced costs, now expanding to diverse centers to measure effectiveness and real-world impact. The study uses an implementation approach to understand how hospitals adopt the steps and how it affects outcomes for kids experiencing acute seizures.
Why it matters
Potential benefit: If successful, the approach could help hospitals treat pediatric seizures more quickly, reducing brain injury and death.
How similar studies have gone: A prior single-center study showed rapid, guideline-based treatment improved timing and outcomes.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Ostendorf, Adam P. — Research Inst Nationwide Children's Hosp
- Study coordinator: Ostendorf, Adam P.
Related research
Other NIH-funded projects on the same topics.
-
Microglia Help Finish Seizures and Heal the Brain
Scientists are studying how brain immune cells (microglia) help end severe seizures and repair brain damage, with potential new ideas for people who have had status epilepticus.
-
ARISEN Network pilot funding to advance autoimmune encephalitis and NORSE care
A pilot grants program within the ARISEN network offers small funding to researchers to speed up clinical trials and improve management and treatment of autoimmune encephalitis, Rasmussen syndrome, and NORSE.
-
ARISEN Network: Better Diagnosis and Treatment for Autoimmune Brain Inflammation in Children
A large team at Emory is building ways to diagnose autoimmune brain inflammation in kids earlier and tailor treatments to improve outcomes.
-
ARISEN Network: Patient-centered outcomes in autoimmune brain inflammation and status epilepticus
A nationwide registry study from Emory will collect patient- and caregiver-reported outcomes to understand how neuroinflammatory brain diseases affect people and what helps them most.
-
ARISEN: A regional network to understand autoimmune brain diseases in kids
A national, multi-center effort follows children with autoimmune brain diseases to better understand how their condition progresses and how it affects thinking and everyday life.
-
ARISEN: Advancing research on autoimmune brain diseases and neuroinflammation
This grant supports a Career Enhancement Core to train the next generation of clinician-scientists studying autoimmune brain diseases like autoimmune encephalitis, Rasmussen’s syndrome, and NORSE, with a focus on pediatric cases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.