Understanding how inflammation affects epilepsy after severe seizures
Official title: Inflammatory regulation of epileptogenesis after status epilepticus
Funded at University of Tennessee Health Sci Ctr · NIH-10997442 · Data updated 2026-11-12
This study is looking at how inflammation after long seizures might lead to epilepsy, and it aims to find new ways to help people who have had these serious seizures avoid developing epilepsy in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | August 3, 2018 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $346,500 |
| NIH project number | 5R01NS100947-08 |
| Project ID | NIH-10997442 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced status epilepticus and are at risk of developing epilepsy.
✕Less likely to help
Patients who have not experienced status epilepticus or those with pre-existing epilepsy may not benefit from this research.
What this research studies
This research investigates the role of inflammation in the development of epilepsy following status epilepticus, a serious condition characterized by prolonged seizures. The study aims to identify the biological signaling pathways activated during and after these seizures, which may lead to long-term neurological issues. By exploring these mechanisms, the research seeks to develop new strategies to prevent or modify the onset of epilepsy in patients who have experienced status epilepticus. Patients who participate may undergo assessments and treatments that target these inflammatory processes.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the development of epilepsy in patients who have suffered from status epilepticus.
How similar studies have gone: Previous research has shown promise in understanding the inflammatory mechanisms involved in epilepsy, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Tennessee Health Sci Ctr
Memphis, United States Active
Researchers
- Principal investigator: Jiang, Jianxiong — University of Tennessee Health Sci Ctr
- Study coordinator: Jiang, Jianxiong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.