Investigating the causes and outcomes of childhood status epilepticus in Nigeria
Official title: Childhood Status Epilepticus and Epilepsy Determinants of Outcome (SEED)
Funded at Vanderbilt University Medical Center · NIH-10833085 · Data updated 2026-11-12
This study is looking at how to better understand and help children in sub-Saharan Africa who have a serious seizure condition called status epilepticus, especially those who experience it as their first seizure, by finding out what factors might affect their recovery and development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | August 1, 2020 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $658,832 |
| NIH project number | 5R01NS118483-05 |
| Project ID | NIH-10833085 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who experience status epilepticus, particularly those presenting to pediatric emergency rooms in Kano, Nigeria.
✕Less likely to help
Patients who do not have status epilepticus or are outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research focuses on understanding childhood status epilepticus (SE), a serious neurological emergency that affects children, particularly in sub-Saharan Africa. The study aims to identify clinical and genomic predictors of mortality and neurodevelopmental issues associated with SE in children who experience it as their first seizure. By establishing a large cohort of affected children in Kano, Nigeria, the research will analyze various factors that contribute to SE and its outcomes, utilizing insights from the H3Africa consortium for genomic studies. This approach will help in understanding the unique challenges faced by children in this region.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and better outcomes for children suffering from status epilepticus.
How similar studies have gone: While research on status epilepticus exists, this specific focus on childhood SE in sub-Saharan Africa is relatively novel and aims to fill significant knowledge gaps.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Trevathan, Edwin — Vanderbilt University Medical Center
- Study coordinator: Trevathan, Edwin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.