Comparing different forms of nicotine in vaping

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study involves experienced electronic cigarette users who will vape three different forms of nicotine: natural, synthetic, and a 50:50 mixture of both. It aims to compare how these forms of nicotine are metabolized in the body, their cardiovascular effects, and how they influence users' cravings, withdrawal symptoms, and enjoyment. Participants will undergo a crossover design, allowing them to experience each form of nicotine in a controlled setting. The findings could provide insights into the pharmacokinetics and pharmacodynamics of nicotine in vaping.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy on the basis of medical history and limited physical examination.
* Current regular user of E-Cigarettes (≥ 15 days in the past 30 days)

Exclusion Criteria:

* • Medications

  * Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs).
  * Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers).
  * Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum).
  * Any stimulant medications (example: Adderall) generally given for ADHD treatment.

    • Pregnancy
  * Pregnancy (self-reported and urine pregnancy test)
  * Breastfeeding (determined by self-report)
  * Women of childbearing potential must be using an acceptable method of contraception

    * Inability to read and write in English
    * A known propylene glycol/vegetable glycerin allergy
    * Uncomfortable with getting blood drawn

Where it's running

• Zuckerberg San Francisco General Hospital (ZSFG)
  San Francisco, California, United States Recruiting

Study contacts

• Principal investigator: Neal Benowitz, MD — University of California, San Francisco
• Study coordinator: Lisa Lawrence
• Email: lisa.lawrence@ucsf.edu
• Phone: 628-206-4204

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.