Community-based smoking cessation program for adults with high stress sensitivity

Efficacy and Implementation of Exercise-based Smoking Cessation Treatment for Adults With High Anxiety Sensitivity.

Phase 3 Interventional University of Texas at Austin · NCT06053567

This study is testing a personalized smoking cessation program that includes counseling and exercise to see if it helps adults with high anxiety sensitivity quit smoking more effectively.

Quick facts

PhasePhase 3
Study typeInterventional
Enrollment360 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Texas at Austin Academic / other
Locations1 site (Austin, Texas)
Trial IDNCT06053567 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the effectiveness of a personalized smoking cessation intervention tailored for adults with high anxiety sensitivity. Participants will receive counseling and nicotine replacement therapy, and will be randomly assigned to either a high-intensity or low-intensity exercise program to enhance smoking cessation outcomes. The intervention is designed to be implemented in community settings, specifically through YMCA facilities, targeting racially and ethnically diverse populations. The study will assess whether this approach can improve smoking cessation rates among individuals who are particularly sensitive to anxiety.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older who are daily smokers with high anxiety sensitivity and are motivated to quit.

Not a fit: Patients who engage in regular vigorous exercise or are currently receiving smoking cessation interventions may not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly improve smoking cessation rates among individuals with high anxiety sensitivity, leading to better overall health outcomes.

How similar studies have performed: Other studies have shown promise in using exercise and counseling for smoking cessation, but this specific community-based approach is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult (age ≥ 18);
* High Anxiety Sensitivity (≥5 on the Short Scale Anxiety Sensitivity Index \[SSASI\]);
* Daily smoker, ≥5 cigarettes (including e-cigarettes, little cigars/cigarillos) for ≥1 year;
* Motivated to quit smoking as evidenced by a score of ≥5 on a 0-10 Likert scale;
* Body mass index \<40;
* Medical clearance to participate.
* Located near a participating YMCA site (within 50 miles)

Exclusion Criteria:

* Regular exercise defined as engaging in vigorous-intensity exercise for at least 75 minutes per week for the last 3 months
* Receiving current intervention for smoking cessation.
* Outstanding debt to the YMCA
* Listed as a sex offender on the National Sex Offender Registry

Where this trial is running

Austin, Texas

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Nicotine Dependence
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.