Understanding how surgery affects brain function in at-risk patients
Mechanisms Mediating Postoperative Neurocognitive Disorders
This study is looking at how surgery might affect thinking and memory in patients who are more likely to have problems afterward, like those with sleep apnea, and it aims to find ways to help these patients feel better after their operations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10692867 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind Postoperative Neurocognitive Disorders (PNCD), particularly in patients who are at higher risk, such as those with obstructive sleep apnea. The project involves advanced brain imaging techniques and cognitive assessments to better understand how surgery may impact cognitive function. Dr. Vacas, the principal investigator, is receiving training and mentorship to develop her skills in clinical science and data analysis, which will enhance the quality of the research. The goal is to identify factors that contribute to cognitive decline after surgery, ultimately aiming to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with obstructive sleep apnea or other conditions that may predispose them to postoperative cognitive issues.
Not a fit: Patients who are not undergoing surgery or do not have risk factors for postoperative cognitive disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for preventing cognitive decline in patients undergoing surgery.
How similar studies have performed: Previous research has shown promising results in understanding cognitive impairment related to surgery, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Vacas, Susana — Massachusetts General Hospital
- Study coordinator: Vacas, Susana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.