Detecting Alzheimer's and mood disorders through voice analysis
Early Detection of Alzheimer's Disease and Affective Disorders by Automated Voice and Speech Analysis
This study is testing whether analyzing voice patterns can help detect Alzheimer's and mood disorders without needing invasive tests like spinal taps or scans.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 50 Years to 100 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Nice Academic / other |
| Locations | 1 site (Nice) |
| Trial ID | NCT05943834 on ClinicalTrials.gov |
What this trial studies
The PLATA project aims to develop an algorithm that identifies vocal biomarkers associated with Alzheimer's disease and affective disorders. By analyzing speech patterns collected during routine care, the study will compare these patterns to established biomarkers like amyloid 1-42 and p-Tau found in cerebrospinal fluid. This innovative approach could potentially eliminate the need for invasive procedures such as lumbar punctures and PET scans for early detection of these conditions.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 50 and older with a diagnosis of mild cognitive impairment or very mild dementia.
Not a fit: Patients with significant hearing problems or those under legal protection may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-invasive method for early detection of Alzheimer's disease and mood disorders.
How similar studies have performed: While the approach of using vocal biomarkers is innovative, similar studies have shown promise in identifying cognitive disorders through speech analysis.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 50 years * Diagnosis relevant biomarker and neuropsychological data already available * Cognitively healthy to very mild dementia (CDR score max. 0.5) * Sufficient knowledge of the study language to understand study information, non opposition form,and questionnaires * Expression of non opposition Exclusion Criteria: * Hearing problems * Patient protected by law, under guardianship or curator ship, or not able to participate in a clinical study according to the article L.1121-16 of the French Public Health Code
Where this trial is running
Nice
- CHU de Nice — Nice, France (Recruiting)
Study contacts
- Principal investigator: Eric ETTORE, MD — Centre Hospitalier Universitaire de Nice
- Study coordinator: Eric ETTORE, MD
- Email: ettore.e@chu-nice.fr
- Phone: 04.92.03.47.70
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.