Combining cognitive assessments with brain monitoring to prevent cognitive disorders after surgery in older patients
Official title: Developing a novel system combining cognitive assessment with PASCALL FDA-cleared intraoperative anesthesia EEG brain monitor to prevent postoperative neurocognitive disorders in aging patients
Funded at Pascall Systems, Incorporated · NIH-10760816 · Data updated 2026-11-12
This study is looking to make anesthesia safer for older patients by using a special brain monitor during surgery to help doctors avoid giving too much sedation, which can sometimes cause memory problems afterward.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pascall Systems, Incorporated NIH-funded |
| Lab location | 1 site (Boston, UNITED STATES) |
| Project start | September 30, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $299,893 |
| NIH project number | 1R42AG084399-01 |
| Project ID | NIH-10760816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly patients aged 65 and older who are scheduled for surgeries requiring general anesthesia.
✕Less likely to help
Patients who are not undergoing surgery or those younger than 65 years may not benefit from this research.
What this research studies
This research aims to enhance the safety of anesthesia for older patients by integrating cognitive assessments with a newly developed brain monitoring system. The PASCALL Wireless EEG monitor, which has received FDA clearance, will be used during surgery to prevent over-sedation, a common issue that can lead to postoperative neurocognitive disorders. By developing a specific test battery and algorithms, the project seeks to identify patients at higher risk for these disorders and provide tailored anesthesia care. This innovative approach could significantly improve outcomes for elderly patients undergoing surgery.
Why it matters
Potential benefit: If successful, this research could reduce the incidence of postoperative cognitive disorders in older patients, leading to better recovery and lower healthcare costs.
How similar studies have gone: Previous research has shown promise in using brain monitoring to improve anesthesia safety, making this approach both innovative and building on existing knowledge.
Where this research is happening
-
Pascall Systems, Incorporated
Boston, United States Active
Researchers
- Principal investigator: Le Mau, Tuan — Pascall Systems, Incorporated
- Study coordinator: Le Mau, Tuan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.