Using brain stimulation to treat apathy in Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of repetitive transcranial magnetic stimulation (rTMS) as a treatment for apathy in individuals with Alzheimer's disease. Participants will include those receiving methylphenidate, a medication known to improve apathy, and those not on any medication. The study aims to assess the effectiveness of rTMS in alleviating symptoms of apathy, which is a common and debilitating condition in dementia. The trial will include individuals diagnosed with major neurocognitive disorders who have experienced apathy for at least four weeks.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* mild or major neurocognitive disorder OR mild behavioural impairment
* Apathy for at least 4 weeks
* Stable dose of medication (\>4 weeks) that may affect cognition or behaviour
* Care partner who spends at least 10 hours a week with the subject

Exclusion Criteria:

* Current major depressive episode
* Agitation, delusions, hallucination
* Medical contraindications to rTMS
* Currently taking an amphetamine product
* Central nervous system abnormalities, Tourette's syndrome, or motor tics
* Current participation in another clinical trial

Where it's running

• Sunnybrook Health Sciences Centre
  Toronto, Ontario, Canada Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.