Vascular factors and HIV-related brain changes in HIV-positive people
Official title: Vascular contributions to HIV-associated Neurocognitive Disorders (HAND)
Funded at Columbia University Health Sciences · NIH-11175393 · Data updated 2026-11-12
This grant supports studying how blood vessel problems and HIV together affect brain aging and dementia risk in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $1,584,605 |
| NIH project number | 4R01AG076383-04 |
| Project ID | NIH-11175393 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV who are aging and at risk for cerebrovascular disease and cognitive impairment.
✕Less likely to help
Individuals without HIV or without the risk factors for cerebrovascular disease may not benefit from this research.
What this research studies
As people with HIV age, they may experience more blood vessel problems and cognitive decline. This project looks at how vascular risk factors and social factors like income and stress influence brain health in HIV-positive individuals, using blood biomarkers such as VCAM-1, ICAM-1, and TNFα to understand the biology. The team plans to compare HIV-positive participants with similar uninfected controls to see how these markers relate to cerebrovascular disease and cognition. If the biomarkers show a link, they could become targets for therapies to protect brain health in HIV. The work combines clinical assessments with biomarker analysis to identify potential intervention points.
Why it matters
Potential benefit: Understanding vascular and inflammatory pathways could lead to new strategies to prevent or slow cognitive decline in people living with HIV.
How similar studies have gone: Prior studies have linked vascular biomarkers to cognitive outcomes; this project extends findings to the HIV-positive aging population.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Brickman, Adam M — Columbia University Health Sciences
- Study coordinator: Brickman, Adam M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.