Comparing intravenous and inhalational anesthesia in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effects of intravenous anesthesia versus inhalational anesthesia on postoperative outcomes in older adults undergoing elective non-cardiac surgery. It is a single-center, randomized, double-blind study that will enroll 260 participants aged 70 and older. The primary focus is to determine whether intravenous anesthesia can reduce the incidence of postoperative delirium and cognitive dysfunction, as well as improve functional status and patient-reported outcomes. Blood biomarkers will also be assessed to understand their relationship with anesthesia type and postoperative cognitive effects.

Why it matters

Who can join: the full rules

Inclusion criteria:

* Men and women ≥ 70 years
* Sufficient vision and hearing to complete all tests
* Proficient in spoken and written English
* Scheduled for elective, inpatient, noncardiac surgery, expected to last at least 120 minutes requiring general anesthesia

Exclusion criteria:

* Urgent or emergent surgery
* Diagnosed dementia (or MoCA\<19)
* History of Parkinson's disease, major psychiatric disease (Schizophrenia), or severe traumatic brain injury
* Ongoing alcohol or substance abuse (per DSM V criteria)
* Allergy to propofol or sevoflurane
* Personal or family history of malignant hyperthermia
* Planned postoperative intubation
* Brain surgery
* Surgery requiring TIVA or GAS (i.e. cases involving neuromonitoring)
* Surgical procedure requiring general anesthetic occurring within 3 months (before or after) surgical date
* Any patient or perioperative factor considered a contraindication to randomization to either experimental group by the surgeon or anesthesiologist.

Where it's running

• Oregon Health & Science University
  Portland, Oregon, United States Recruiting

Study contacts

• Principal investigator: Katie J. Schenning, MD — Oregon Health and Science University
• Study coordinator: Kimberly N. Chun, BS
• Email: chunk@ohsu.edu
• Phone: 503-494-7437

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.