How HIV affects brain health and blood vessel function in aging patients
Official title: Vascular contributions to HIV-associated Neurocognitive Disorders (HAND)
Funded at Columbia University Health Sciences · NIH-10888208 · Data updated 2026-11-12
This study is looking at how living with HIV affects heart and brain health as people get older, especially in those with other health issues like high blood pressure or diabetes, to find ways to help improve thinking and memory skills.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $805,326 |
| NIH project number | 5R01AG076383-03 |
| Project ID | NIH-10888208 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are aging individuals living with HIV who may be experiencing cognitive decline or have vascular risk factors.
✕Less likely to help
Patients who are not living with HIV or those who do not have any vascular risk factors may not benefit from this research.
What this research studies
This research investigates the relationship between HIV, vascular health, and cognitive function in aging individuals living with HIV. It aims to understand how chronic conditions like hypertension and diabetes, along with socioeconomic factors, contribute to increased rates of cerebrovascular disease and dementia in these patients. By analyzing blood biomarkers related to vascular health, the study seeks to identify potential therapeutic targets that could improve cognitive outcomes. Patients will be compared to age- and sex-matched individuals without HIV to highlight these disparities.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cognitive decline in aging individuals with HIV.
How similar studies have gone: Previous research has shown that addressing vascular health can improve cognitive outcomes in other populations, suggesting potential success for this approach in HIV patients.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Gutierrez, Jose — Columbia University Health Sciences
- Study coordinator: Gutierrez, Jose
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.