Condition

Mood clinical trials and research

• 13Clinical trials
• 75NIH research projects
• 3Countries

Newest Mood clinical trials

All recruiting trials (13)

• Effects of Tyrosol and Creatine on Exercise Performance and Mood

  This study tests whether creatine, tyrosol, or both can improve endurance, strength, and mood in healthy adults over 8 weeks.

  Recruiting Applied Science & Performance Institute · Tampa, Florida · NCT07756658

• BabaCare: Testing a Care Copilot for lonely older adults

  A new AI voice and text companion called Baba is being tested to see if it can help reduce loneliness and improve mood in older adults who live alone.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT07689526

• Morning Bright Light for Better Daytime Functioning in University Students

  This study tests whether a one-week, morning 30-minute bright light session improves sleep quality and daytime alertness and mood in healthy university students.

  Recruiting The Hong Kong Polytechnic University · Hung Hom · NCT07685262

• Personalized binaural and spatial music to help with dementia-related symptoms

  This study tests whether personalized binaural beat music, spatialized music, or both can help reduce behavioral and mood symptoms in older adults with dementia or age-related changes living in assisted living facilities.

  Recruiting at 2 sites Maharishi International University · Denver, Colorado and 1 other locations · NCT07626944

• Psilocybin with or without Pimavanserin Pretreatment in Healthy Adults

  This study tests whether a single 25 mg dose of psilocybin, given with or without pimavanserin pretreatment or placebo, affects mood and well-being in healthy adults over one month.

  Recruiting Phase 1/2 Johns Hopkins University · Baltimore, Maryland · NCT07610135

• Novel functional snack and perimenopause: does a fibre- and phytochemical-rich bite help symptoms?

  A daily snack enriched with phytochemicals and fiber is being tested to see if it can reduce perimenopausal symptoms and improve well-being in women aged 40–55 who are not using hormone therapy.

  Recruiting King's College London · London, London · NCT07599930

• Collagen supplement to improve quality of life, appetite and blood sugar in adults with overweight or obesity

  This trial will try an 8-day collagen peptide supplement to see if it improves quality of life, appetite and short-term blood sugar control in adults aged 18–65 who are overweight or have obesity and feel their quality of life is low.

  Recruiting King's College London · London, London · NCT07229014

• Theater and arts program to build resilience and reduce anxiety in children and teens

  This program will test whether adding CBT techniques to theatrical improvisation, improvisation alone, or a social craft group helps reduce anxiety and depression in children and adolescents with elevated symptoms.

  Recruiting Case Western Reserve University · Cleveland, Ohio · NCT07033052

• Losartan plus activity scheduling for low positive mood

  This study tests whether seven days of losartan taken with a short behavioural activation program helps people with low positive mood process positive information better than placebo.

  Recruiting Early Phase 1 University of Oxford · Oxford, Oxfordshire · NCT07017023

• Using Shatavari to treat menopausal symptoms in women

  This study is testing if Shatavari can help women aged 45 to 65 feel better during menopause by reducing symptoms like hot flashes and mood swings.

  Recruiting SF Research Institute, Inc. · San Francisco, California · NCT06716554

• Examining morning exercise effects on sleep and mood in college students

  This study tests if exercising in the morning can help college students sleep better and feel happier compared to those who stick to evening workouts.

  Recruiting at 6 sites Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 5 other locations · NCT06336590

• Exploring the relationship between sleep health and overall well-being

  This study is trying to see how sleep affects both physical and mental health by tracking the sleep and activity of people using digital devices.

  Recruiting Scripps Translational Science Institute · La Jolla, California · NCT05197738

• Effects of hormonal contraceptives on mood and brain activity

  This study is testing how taking hormonal birth control affects mood and brain activity in adult women.

  Recruiting Phase 4 University of Colorado, Denver · Aurora, Colorado · NCT05058872

NIH-funded research (newest 40 of 75)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Doula support to improve mood and anxiety health for rural mothers

  A rural-focused program tests whether birth doulas can boost confidence, support, and maternal health for new mothers with mood and anxiety concerns.

  NIH research University of Montana · Missoula, United States · NIH-11632168

• How pesticide spray seasons affect thinking and mood in teens and young adults

  This project follows teens and young adults for two years to look for short-term changes in thinking skills and mood linked to nearby pesticide spray seasons.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11504813

• Sleep and mood links in Fragile X Syndrome

  A short, patient-friendly study to understand how sleep problems relate to mood and depressive symptoms in people with Fragile X–linked autism.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11456853

• Single-cell study of mood-regulation brain circuits in depression

  A large study will map which genes and cell types in mood-related brain circuits are linked to major depressive disorder, including differences by ancestry and sex.

  NIH research Centre de Recherche de L'hopital Douglas · Montreal, Canada · NIH-11421431

• Single-cell map of mood circuits in major depressive disorder

  Researchers will map the tiny brain cells in mood-control areas to understand how genes and cell types relate to depression, with attention to ancestry and sex.

  NIH research Lieber Institute, INC. · Baltimore, United States · NIH-11418004

• Perinatal Mood and Anxiety Care Lab to help families after childbirth

  A hospital-based program will test easier, faster screening and referral for postpartum depression in new mothers and parents of infants in NICUs and PEDs to get timely help.

  NIH research Children's National Medical Center · Washington, United States · NIH-11414760

• Understanding how mood swings happen in bipolar disorder

  Researchers are testing a high-tech brain imaging approach to map how emotions flare and fade in people with bipolar disorder.

  NIH research Laureate Institute for Brain Research · Tulsa, United States · NIH-11413545

• Improve mood to help adults with methamphetamine use disorder make better choices

  This project tests a mood-improvement approach to help adults with methamphetamine use disorder choose healthier options more often.

  NIH research Laureate Institute for Brain Research · Tulsa, United States · NIH-11413543

• Mindfulness program in clinics to help mood and diabetes management for teens with Type 1 diabetes

  A practical mindfulness-based program delivered in clinics aims to help mood problems and improve diabetes management for young people with Type 1 diabetes.

  NIH research Children's Research Institute · Washington, United States · NIH-11401454

• Actify: a mobile tool to help people quit smoking by managing mood

  A mobile app called Actify! helps people quit smoking by addressing depressive mood as part of the quit plan.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11400405

• Preventing Mood and Anxiety Problems After Cesarean Delivery

  A low-cost, one-hour intervention given to pregnant patients having a cesarean delivery to help reduce mood, anxiety, and trauma symptoms later on.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11394478

• Mood-state classifiers to guide brain stimulation for treatment-resistant bipolar depression

  This project tests a brain stimulation therapy combined with wearable and smartphone data to help people with treatment-resistant bipolar depression regain mood stability.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11392518

• Serotonin in the gut and brain: targeted drug delivery for gut-brain disorders and mood symptoms

  The team will learn how serotonin in the gut lining versus gut nerves affects digestive and mood symptoms to create targeted treatments for people with chronic gut-brain disorders and anxiety or depression.

  NIH research New York University · New York, United States · NIH-11370124

• Perinatal Cannabis Use and Maternal Mood: A Real-Time Study Across Pregnancy and Postpartum

  A real-time study follows pregnant and new mothers to understand how mood and physical symptoms relate to cannabis use during pregnancy and after birth.

  NIH research Butler Hospital (Providence, Ri) · Providence, United States · NIH-11360684

• Neuromodulation clues in late-life depression and its impact on mood, thinking, and daily function

  This study looks at how brain chemical systems linked to mood and movement lie behind late-life depression and its effects on thinking and frailty in older adults.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11357619

• Hormonal drivers of perimenopausal inflammation and mood symptoms

  This grant studies how hormonal changes during perimenopause may spark inflammation and mood symptoms, with the aim of helping adult women understand and manage these experiences.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11355626

• Understanding gene activity in the brains of people with mood disorders who died by suicide

  A study to map which genes are active in brain cells and where they are in the brains of people with mood disorders who attempted or died by suicide, using advanced single-cell and spatial techniques.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11349216

• Synaptic changes in mood disorders and suicide risk

  This project studies brain Synapse signals in people with mood disorders, including those with a recent suicide attempt, to understand what changes are linked to suicide risk and how ketamine might work.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11349215

• Integrating immune and brain reward biology in veterans with mood problems

  A study in veterans with mood disorders looks at how the immune system and brain reward circuits may work together to drive depression and suicide risk.

  NIH research James J Peters VA Medical Center · Bronx, United States · NIH-11320777

• Understanding brain circuits that shape mood using direct brain recordings

  This project uses direct brain recordings and explainable AI to find brain activity patterns linked to depression in people undergoing intracranial monitoring or deep brain stimulation.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11308208

• Sex differences in how respiratory-gated tVNS affects brain, mood, and heart health in major depression

  A study at a major hospital will test whether a breathing-linked ear nerve stimulation helps mood and brain signals differently for men and women with major depression.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11301318

• Impact of prenatal immune dysregulation on brain networks related to mood in major depression

  This project looks at how immune system changes before birth may influence brain networks tied to mood and mood disorders in adults.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11301317

• Seasonal farm pesticide effects on thinking and mood in teens and young adults

  Looking at whether pesticide spray seasons are linked to temporary changes in thinking skills and mood in teens and young adults from the ESPINA group.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11300242

• Mindfulness for mood and heart health during pregnancy

  A mindfulness-based program for pregnant and postpartum people to help mood and heart health during the perinatal period.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11294004

• Mindfulness to reduce mood swings in teens at risk for mood disorders

  This project teaches mindfulness skills to teens and young adults with family histories of mood disorders to help reduce frequent mood swings and improve sustained attention.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11285153

• Smartphone-based mood and emotion monitoring for bipolar disorder

  This project uses an Android app that passively tracks voice and behavior to spot mood and emotion changes in people with bipolar disorder.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11231253

• Group prenatal care to support mood before and after birth

  This project compares group prenatal care (CenteringPregnancy) with usual prenatal care to help pregnant people feel better during pregnancy and after their baby is born.

  NIH research Meredith College · Raleigh, United States · NIH-11221634

• Mapping cell and gene changes in the brain linked to depression

  Mapping genes and cell types in key mood-regulating brain regions from people with major depressive disorder, including diverse ancestries and both sexes.

  NIH research Centre de Recherche de L'hopital Douglas · Montreal, Canada · NIH-11184481

• Single-cell map of mood-regulating brain regions in depression

  Researchers will make a detailed cellular map of key brain areas that control mood to find molecular changes linked to major depression and how these vary by ancestry and sex.

  NIH research Lieber Institute, INC. · Baltimore, United States · NIH-11184427

• Mindfulness program to help mood and diabetes care in young people with Type 1 diabetes

  This offers a short, clinic-based group mindfulness program to help teens and young people with Type 1 diabetes manage mood, stress, and daily diabetes care.

  NIH research Children's Research Institute · Washington, United States · NIH-11184355

• Brain implants and wearables to monitor and help severe bipolar depression

  This project uses an implanted brain stimulator together with phone and wearable data to detect mood patterns and help people whose bipolar depression hasn't responded to other treatments.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11178411

• Investigating hormonal changes during perimenopause and their effects on mood and inflammation

  This study is looking at how hormonal changes during perimenopause might cause more inflammation and mood issues like anxiety and depression in women, with the goal of finding ways to help those who are struggling with these symptoms.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11176931

• How regular cannabis vaping affects mood, thinking, and metabolism after menopause

  Researchers expose menopause-model mice to regular cannabis vapor to learn how it may change mood, memory, and metabolism relevant to people after menopause.

  NIH research Washington State University · Pullman, United States · NIH-11159857

• Improving depression and anxiety care for new parents at a children's hospital

  This program is creating easy, one-stop screening and treatment for postpartum depression and anxiety for parents whose babies are treated at a children's hospital.

  NIH research Children's National Medical Center · Washington, United States · NIH-11145695

• Improving mood to help decision-making in adults recovering from methamphetamine use

  This project uses positive personal memory recall to lift mood and help adults recovering from methamphetamine use make better, less drug-focused choices.

  NIH research Laureate Institute for Brain Research · Tulsa, United States · NIH-11145212

• Stepped care for pregnancy-related mood and anxiety for women with HIV in Kenya

  This project brings routine mental-health screening, brief counseling, and remote psychiatric care together to help pregnant and postpartum women living with HIV in Kenyan clinics who have depression or anxiety.

  NIH research Kenyatta National Hospital · Nairobi, Kenya · NIH-11144411

• Understanding how calcium channels affect substance use and mood disorders

  This study is looking at how problems with drugs and mood can affect each other, especially when someone is trying to stay off drugs, and it’s testing how certain brain channels might help us find better treatments for people dealing with both issues.

  NIH research Yale University · New Haven, United States · NIH-11144027

• Immune and metabolic gene patterns tied to depression in people with HIV

  This project looks at immune and metabolism-related genes to find links to low mood and loss of pleasure in adults living with HIV.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11123505

• Understanding Cannabis Use in Pregnant and New Mothers

  This research aims to understand why pregnant and new mothers choose to use cannabis, looking at how their mood and physical symptoms might play a role.

  NIH research Butler Hospital (Providence, Ri) · Providence, United States · NIH-11105958

• Improving decision-making in adults recovering from amphetamine use disorder by enhancing mood

  This study is looking at how feeling better can help people recovering from amphetamine use make smarter choices, and it uses fun memory exercises to lift their mood while checking how their brains work during decision-making.

  NIH research Laureate Institute for Brain Research · Tulsa, United States · NIH-11093606

Related topics

Quick answers

How many Mood clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 3 countries. The most sites are in United States (9 trials), United Kingdom (3 trials), Hong Kong (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Early Phase 1: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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