Effects of Tyrosol and Creatine on Exercise Performance and Mood

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind, placebo-controlled trial compares creatine monohydrate, tyrosol, and their combination against placebo over an 8-week period in healthy adults. Participants will undergo baseline and end-of-study tests for body composition, cognition, mood, fatigue, and full-body strength, including bench press 5RM and endurance-to-failure assessments. Testing days require standardized diets, avoidance of high-intensity workouts for 72 hours, and avoidance of caffeine and alcohol prior to visits. The study uses a fixed weight protocol to control training stimulus and will measure fatigue curves and cognitive performance to explore potential synergistic effects. Primary interventions are 5 g/day creatine, 150 mg/day tyrosol, and placebo, with outcomes analyzed for duration of exercise performance and cognitive domains.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy males aged 20-55
* Currently active (engaged in moderate to vigorous activity at least 2-days per week as defined by the American College of Sports Medicine Guidelines)
* Estimated VO2 max greater than the 40th percentile of the population norm for age (assessed via ACSM guidelines, 2014). The VO2 max estimation at screening will be obtained by following a non-exercise regression model validated and described by Bradshaw et al. (2005).
* Able to read and write in English
* During the study, agree not to take any other supplements that may increase muscle strength or endurance (e.g. protein formulas, creatine, amino acids, tyrosol or stimulants other than caffeine).
* During the study, subjects will not deviate from their normal daily routine unless it conflicts with study criteria. This includes maintaining their present workout routine and diet, without substantial changes.

Exclusion Criteria:

* Known diagnosis of any cardiovascular, metabolic, endocrine, or renal disease
* Uncontrolled stage II hypertension or higher
* Recent musculoskeletal injury (\<3-months)
* Recent orthopaedic surgery (\<12-months)
* History of or current malignancy
* Previous gastrointestinal surgery within the past 12 months
* Regular smoker
* Regular drinker (\>14 drinks per week)
* Current use (within the past 5 weeks) of creatine supplements
* Current use (within past 3 months) of Tyrosol supplementation
* Current use of dietary supplements that may enhance mitochondrial function, muscle hypertrophy, or muscle strength (e.g. protein formulas, creatine, amino acids, tyrosol, etc.).
* Current use of prescription medications that may influence adaptation to exercise (hormone therapies, peptides, etc.)

Where it's running

• Applied Science and Performance Institute
  Tampa, Florida, United States Recruiting

Study contacts

• Principal investigator: Eric Sikorski, PhD — Applied Science and Performance Institute
• Study coordinator: Eric Sikorski, PhD
• Email: esikorski@theaspi.com
• Phone: 8138678888

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.