Seasonal farm pesticide effects on thinking and mood in teens and young adults

Cyclical Alterations In Neurocognitive Performance And Mood Over Two Years In Relation To Pesticide Spray Seasons Among Adolescent And Young Adult Participants Of The Espina Study.

NIH-funded research University of California, San Diego · NIH-11300242

Looking at whether pesticide spray seasons are linked to temporary changes in thinking skills and mood in teens and young adults from the ESPINA group.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of California, San Diego NIH-funded
Lab location1 site (La Jolla, United States)
Project IDNIH-11300242 on NIH RePORTER

What this research studies

This project follows about 550 adolescents and young adults from the ESPINA cohort over two years to see if their cognition and mood change during local pesticide spray seasons. Researchers will repeat cognitive tests and mood questionnaires during and outside spray periods and collect biological samples and exposure timing information. The team will link short-term exposure markers to any temporary declines in attention, memory, or increases in anxiety and impulsive behaviors. Findings aim to identify when young people may be most vulnerable and suggest ways to reduce exposure or protect health.

Who could benefit from this research

Good fit: Ideal candidates are adolescents and young adults enrolled in the ESPINA cohort or living in agricultural areas with seasonal pesticide spraying who can attend repeated study visits and provide biological samples.

Not a fit: People who do not live near agricultural spray zones or who cannot commit to repeated testing and sample collection are unlikely to benefit directly from participation.

Why it matters

Potential benefit: If successful, the work could identify times when pesticide exposure temporarily harms thinking or mood in young people and inform strategies to reduce exposure or protect them.

How similar studies have performed: Prior research links organophosphate exposures to cognitive changes and some mood effects, but repeatedly measuring short-term cycles across spray seasons in this age group is relatively new.

Where this research is happening

La Jolla, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.