Condition

Circadian Rhythm clinical trials and research

• 19Clinical trials
• 51NIH research projects
• 1New in 30 days
• 8Countries

Newest Circadian Rhythm clinical trials

All recruiting trials (19)

• Sleep and circadian care for ICU patients

  This study tests a multicomponent sleep and circadian rhythm program in adult ICU patients to see if it helps keep daily rhythms and sleep better.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT07869901

• Overnight Temperature Regulation to Test Gut Health, Inflammation, and Circadian Rhythms

  This study tests whether two weeks of using the Eight Sleep Pod at night can improve gut bacteria balance, lower inflammation, and strengthen daily temperature and blood pressure rhythms in postmenopausal women and age-matched men with poor sleep.

  Recruiting Eight Sleep Inc. · Newton Center, Massachusetts · NCT07848594

• Morningness vs. eveningness and how quickly healthy adults recover after submaximal exercise

  This study tests whether people who prefer morning or evening are linked to how quickly healthy adults recover after a light-to-moderate workout.

  Recruiting Saglik Bilimleri Universitesi · Istanbul · NCT07833956

• Morning Bright Light for Better Daytime Functioning in University Students

  This study tests whether a one-week, morning 30-minute bright light session improves sleep quality and daytime alertness and mood in healthy university students.

  Recruiting The Hong Kong Polytechnic University · Hung Hom · NCT07685262

• Chronotype and time-of-day test of time perception in morning and evening types

  This study tests whether matching a person’s chronotype (morning or evening) with the testing time (morning or evening) changes how accurately they perceive time.

  Recruiting The Hong Kong Polytechnic University · Hong Kong · NCT07677111

• Early pregnancy lifestyle patterns and glucose changes in a TOFFFY sub-study

  This study tests whether daily patterns like sleep, activity, and meal timing in early pregnancy affect glucose levels and the risk of gestational diabetes, using CGM and wearable data in pregnant women in Singapore.

  Recruiting KK Women's and Children's Hospital · Singapore, Singapore · NCT07534670

• Sleep loss and circadian misalignment and insulin resistance: how cortisol timing might help

  This study tests whether changing cortisol timing with hormones and sleep schedules can influence insulin resistance in healthy adults who sleep restrictively.

  Recruiting Phase 4 Washington State University · Spokane, Washington · NCT07494084

• Nighttime synchronization of eating and your circadian clock

  This trial will test whether changing light exposure and when you eat during short sleep periods changes metabolism in healthy adults aged 18–35 who normally sleep 7–9 hours per night.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07329283

• Effect of Esketamine on Postoperative Sleep in Postmenopausal Women

  This study tests whether esketamine can improve sleep after surgery in postmenopausal women.

  Recruiting at 2 sites Yangzhou University · Jingjiang, Jiangsu and 1 other locations · NCT07315074

• How the body clock affects time perception during 36 hours awake

  This test will see if the internal body clock and staying awake for about 36 hours change how healthy adults experience and estimate time.

  Recruiting University of Aarhus · Aarhus · NCT07294781

• How your body clock changes how you perceive time

  This project will test whether being tested at your preferred or opposite time of day changes time estimation, time production, and vigilance in healthy Danish adults who are clearly morning- or evening-types.

  Recruiting University of Aarhus · Aarhus · NCT07292597

• Wearable tools to support dementia care in rural Taiwan

  This project will test whether a wrist activity tracker and light-therapy glasses are easy to use and can help people with Alzheimer's dementia and their family caregivers in rural Taiwan.

  Recruiting China Medical University Hospital · Beigang, Yunlin · NCT07249918

• How a Western versus a fiber-rich diet affects sleep and daily body rhythms

  It will test whether eating a Western-style unhealthy diet versus a healthier, fiber-rich diet changes sleep quality and daily heart, glucose, and hormone rhythms in healthy young adults.

  Recruiting Uppsala University · Uppsala · NCT07138313

• Effects of cannabis on sleep and light sensitivity in young adults

  This study tests how using and stopping cannabis affects sleep and light sensitivity in young adults aged 18 to 25.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06743373

• Effects of Sleep Regularity on Heart and Metabolic Health

  This study is testing if sticking to a regular sleep schedule can improve heart and metabolic health in healthy adults aged 18 to 40.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT06535178

• Investigating melatonin phase delay in children with idiopathic scoliosis

  This study is trying to see if a delay in melatonin levels is common in children with newly diagnosed idiopathic scoliosis and if it might be linked to their condition.

  Recruiting Second Affiliated Hospital of Wenzhou Medical University · Wenzhou, Zhejiang · NCT06502613

• Examining how evening light and media affect children's sleep and emotions

  This study is testing how different types of evening screen time, like bright or dim lights and calming or exciting shows, affect the sleep and emotions of kids aged 8 to 11.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT06192745

• Dynamic lighting to improve sleep and circadian rhythm in frail older adults

  This test will try dynamic, spectrum-changing hospital room lighting to improve sleep and circadian rhythms for people aged 65 and older during their hospital stay.

  Recruiting Region Skane · Malmö · NCT05107947

• Investigating how diet affects our internal body clock

  This study is testing how high-fat and low-fat diets affect our body's internal clock and how quickly we can adjust to changes in light when eating these diets.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT04743271

NIH-funded research (newest 40 of 51)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Circadian control of brain blood vessels in Alzheimer’s disease

  A researcher at Emory is studying how daily biological rhythms influence the brain’s blood vessels to improve brain drug delivery in Alzheimer’s disease.

  NIH research Emory University · Atlanta, United States · NIH-11450536

• Understanding the biology behind Delayed Sleep-Wake Phase Disorder (DSWPD) and new treatment ideas

  This NIH grant aims to understand why some people, including teens and adults, have DSWPD and how to develop better circadian-based treatments to improve sleep and daily functioning.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11408692

• Sleep, circadian rhythms, and the brain’s reward system in teens

  A study in teens aims to understand how sleep patterns and daily rhythms influence risk-taking and substance use by looking at brain circuits involved in reward and control.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11399195

• Circadian Rhythm Sleep Disorder: Understanding Why Some People Sleep Late

  A study at Northwestern University is exploring why some people with delayed sleep patterns have different light sensitivity and how this affects their sleep timing, with the goal of personalizing treatment for those with DSWPD.

  NIH research Northwestern University · Chicago, United States · NIH-11396461

• Sleep and circadian factors linked to opioid treatment outcomes

  A long-term study at Johns Hopkins will follow people on buprenorphine or methadone to see how sleep quality and daily rhythms relate to ongoing opioid use.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11394555

• Exercise timing to reset the brain’s body clock in breast cancer care

  A study tests whether exercising at specific times can reset the brain’s circadian clock and potentially improve well-being for people coping with breast cancer.

  NIH research University of Wyoming · Laramie, United States · NIH-11388639

• Understanding how sleep and body rhythms affect cravings and emotion control for people on opioid treatment

  This project looks at how sleep patterns and body clocks influence cravings and emotion regulation in people taking medication for opioid use disorder.

  NIH research Emma Pendleton Bradley Hospital · Riverside, UNITED STATES · NIH-11385557

• Circadian rhythms as a target to protect the heart around surgery

  A study to see if adjusting or aligning body clock signals can help protect patients’ hearts during and after surgery.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11378303

• REV-ERB clock receptors linked to daily rhythms and metabolism

  A human-dafety oriented research grant exploring how liver clock signals influence brain control of food intake to help fight obesity and diabetes.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11364906

• HIV and liver circadian rhythms: how co-infections affect liver health

  This project explores how HIV-related infections and liver conditions interact with our body’s clock to influence liver disease in people living with HIV.

  NIH research Emory University · Atlanta, United States · NIH-11345952

• Glucocorticoid rhythm restoration in breast cancer

  Aims to understand and help restore daily cortisol rhythms in people with breast cancer to improve quality of life and potentially survival.

  NIH research Cold Spring Harbor Laboratory · Cold Spring Harbor, United States · NIH-11345857

• Treating teen depression by targeting sleep and the body clock

  This project offers a sleep- and circadian-focused therapy for teens (ages 12–20) with major depression who tend to stay up late.

  NIH research Children's Hospital of Los Angeles · Los Angeles, United States · NIH-11340260

• Sleep, mood, and mouth bacteria in teens and young adults

  A teen/young adult study will look at how sleep patterns and circadian rhythms relate to the bacteria in the mouth and to depression.

  NIH research Emma Pendleton Bradley Hospital · Riverside, UNITED STATES · NIH-11336433

• Sleep and daily rhythms as factors in chronic pain spread

  This NIH grant explores how sleep and circadian rhythm problems may influence the development and worsening of multiple chronic pain conditions in adults.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11332940

• Body clock and meal timing for healthier aging

  This project looks at whether eating less and timing meals to the body's daily clock helps mice live healthier, longer lives.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11328839

• How prenatal disruption of day–night cycles may raise risk for later substance use

  This project tests whether being exposed before birth to disrupted day–night cycles makes people more likely to develop substance use or mood problems as they grow up.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11295448

• How the brain's body clock affects blood vessel repair in Alzheimer's

  This project looks at whether disruptions in the brain's daily rhythms keep blood vessels from repairing after low blood flow in people living with Alzheimer's.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11285334

• Using genetics to reduce misdiagnosis of narcolepsy and sleep-wake rhythm disorders

  Researchers will create genetic risk scores that work across ancestries to help people with suspected narcolepsy and circadian rhythm sleep-wake disorders get diagnosed more accurately.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11261119

• Examining how disruptions in sleep patterns during pregnancy affect substance use in offspring

  This study looks at how changes in sleep patterns during pregnancy, like those caused by shift work, might affect kids later in life, especially regarding their chances of developing substance use issues, and it aims to find ways to help families impacted by these changes.

  NIH research University of Toledo Health Sci Campus · Toledo, United States · NIH-11245825

• How sleep and the body clock affect teen brain reward pathways

  Researchers are looking at how sleep patterns and the internal body clock change brain circuits that influence reward and substance use risk in adolescents aged about 12–20.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11198102

• Why some adults fall asleep and wake up much later than usual (delayed sleep‑wake timing)

  Researchers are comparing biological and behavioral differences in adults who fall asleep and wake up much later than typical to help tailor better diagnoses and treatments.

  NIH research Northwestern University · Chicago, United States · NIH-11193826

• Understanding delayed sleep-wake phase (night-owl sleep timing)

  This project tests whether detailed sleep and circadian measurements plus a new blood marker can explain and help treat delayed sleep-wake phase disorder in teens and adults.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11187054

• How sleep and your body clock affect cravings and emotions during opioid medication treatment

  This work looks at how sleep patterns and circadian rhythms relate to cravings and emotion control in people taking medications for opioid use disorder.

  NIH research Emma Pendleton Bradley Hospital · Riverside, UNITED STATES · NIH-11175440

• Sleep and body‑clock patterns during opioid treatment

  This project follows people on buprenorphine or methadone to see how sleep and daily body‑clock patterns relate to returning to opioid use.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11171667

• How HIV and liver diseases affect body clock rhythms

  This study is looking at how having HIV and liver diseases can mess with your body's natural sleep and wake cycles, and it's for people living with HIV who want to understand how these issues might affect their health and what new treatments could help.

  NIH research Emory University · Atlanta, United States · NIH-11163530

• How reward sensitivity and the body clock relate to first bipolar episodes in teens

  Researchers are tracking adolescents to learn whether strong reward reactions and disrupted sleep/circadian rhythms can predict a first bipolar episode.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11126831

• Understanding daily hormone rhythms in breast cancer

  This work explores why daily hormone cycles are disrupted in people with breast cancer and how restoring these cycles might help.

  NIH research Cold Spring Harbor Laboratory · Cold Spring Harbor, United States · NIH-11126566

• Understanding how fat tissue affects daily blood pressure rhythms

  This research explores how a substance from fat tissue helps control your daily blood pressure patterns, which is important for preventing heart problems.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11121930

• How eating patterns affect aging and lifespan

  This study looks at how when we eat and our body's natural clock can affect how long and healthy we live, using mice to find out if eating less and at the right times can help us age better, which could lead to helpful diet tips for people.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11079474

• How overnight nutrition affects sleep and circadian rhythms in ICU patients

  This study is looking at whether giving patients in the ICU their meals during the day instead of at night can help them sleep better and feel healthier after heart surgery.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11061889

• Understanding sleep issues in cystic fibrosis patients

  This study is looking at how changes in sleep patterns affect the sleep quality of children and young adults with cystic fibrosis, and it hopes to find ways to help improve their sleep and health.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11060056

• Investigating how sleep and circadian rhythms affect chronic pain conditions

  This study is looking at how sleep problems affect people with chronic pain, especially those with low back pain, to find ways to improve treatment and prevention for everyone dealing with similar issues.

  NIH research Arizona State University-Tempe Campus · Tempe, United States · NIH-11052623

• Using genetics to improve diagnosis of narcolepsy and sleep disorders.

  This study is working to make it easier and faster for people with narcolepsy and sleep-wake disorders to get the right diagnosis by using genetic tests that are affordable and can help everyone, no matter their background.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11051238

• Using a new sleep and circadian rhythm approach to treat depression in teenagers

  This study is looking at a new sleep therapy to help teenagers with depression who like to stay up late, by helping them get their sleep patterns in sync with their natural body clocks to see if it can lift their mood and improve their mental health.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11046522

• How disruptions in sleep patterns affect blood vessel responses in Alzheimer's disease

  This study is looking at how changes in your body's natural clock might affect blood flow and the growth of new blood vessels in the brains of people with Alzheimer's, to better understand how these factors influence thinking and memory.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11015819

• How the body's internal clock affects stress responses and heart health

  This study looks at how our body's internal clock affects the way we respond to stress and how it might impact heart health, especially for people who work night shifts or have unusual schedules.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11005761

• How the body's internal clock affects the blood-brain barrier and inflammation

  This study is looking at how our body's natural daily rhythms affect the blood-brain barrier, which helps keep our brain safe while letting in important nutrients, to find better ways to deliver treatments for brain-related conditions.

  NIH research Emory University · Atlanta, United States · NIH-10995337

• How metabolic diseases affect circadian rhythms and dietary therapy

  This study is looking at how our body’s internal clock affects metabolic diseases, especially in people with Alzheimer's and Parkinson's, to see if fixing sleep patterns and diet can help improve their symptoms.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10993167

• Understanding the causes of delayed sleep-wake phase disorder

  This study is looking at a sleep condition called Delayed Sleep-Wake Phase Disorder (DSWPD) to better understand how different types of it respond to light and sleep, so we can find more accurate ways to diagnose and treat people who have trouble sleeping at night and waking up in the morning.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10937779

• Understanding how sleep affects cravings and emotions in people treated for opioid use disorder.

  This study is looking at how your sleep quality and body clock affect cravings and emotions while you're being treated for opioid use disorder, with the hope of finding ways to improve your recovery by focusing on better sleep.

  NIH research Emma Pendleton Bradley Hospital · Riverside, UNITED STATES · NIH-10932897

Related topics

Quick answers

How many Circadian Rhythm clinical trials are recruiting right now?

19, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (7 trials), China (3 trials), Hong Kong (2 trials), Sweden (2 trials), Denmark (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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