Hormonal drivers of perimenopausal inflammation and mood symptoms
Funded at Icahn School of Medicine at Mount Sinai · NIH-11355626 · Data updated 2026-11-12
This grant studies how hormonal changes during perimenopause may spark inflammation and mood symptoms, with the aim of helping adult women understand and manage these experiences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 26, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $954,279 |
| NIH project number | 5R01MH135079-03 |
| Project ID | NIH-11355626 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older going through or approaching perimenopause who are experiencing mood symptoms.
✕Less likely to help
Individuals not experiencing mood symptoms or not in the perimenopausal transition may not directly benefit.
What this research studies
As a patient going through perimenopause, you might experience mood changes that are not fully explained by aging. This research follows women to map how hormones like FSH, estradiol, and acyl-ghrelin relate to inflammation and mood over time. By examining blood markers and mood data, the team aims to uncover mechanisms that could lead to new treatments or guidance. Results could inform personalized care for mood symptoms during the perimenopausal transition.
Why it matters
Potential benefit: Could lead to better understanding and future therapies to reduce mood symptoms during perimenopause.
How similar studies have gone: Prior research suggests hormonal and inflammatory links to mood are promising targets, though this exact mechanistic pathway is being explored for the first time here.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Spicer, Julie a — Icahn School of Medicine at Mount Sinai
- Study coordinator: Spicer, Julie a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.