Condition

Well-being clinical trials and research

• 11Clinical trials
• 142NIH research projects
• 8Countries

Newest Well-being clinical trials

All recruiting trials (11)

• Probiotic supplementation to support gut health, immune response, and well-being in adults

  In this 8-week study, healthy adults with mild to moderate stress will take a probiotic supplement or placebo daily to see if it affects gut barrier function, immune markers, and well-being.

  Recruiting Orthomol Pharmazeutische Vertiebs GmbH · Trier · NCT07779265

• Personalized binaural and spatial music to help with dementia-related symptoms

  This study tests whether personalized binaural beat music, spatialized music, or both can help reduce behavioral and mood symptoms in older adults with dementia or age-related changes living in assisted living facilities.

  Recruiting at 2 sites Maharishi International University · Denver, Colorado and 1 other locations · NCT07626944

• Psilocybin with or without Pimavanserin Pretreatment in Healthy Adults

  This study tests whether a single 25 mg dose of psilocybin, given with or without pimavanserin pretreatment or placebo, affects mood and well-being in healthy adults over one month.

  Recruiting Phase 1/2 Johns Hopkins University · Baltimore, Maryland · NCT07610135

• Mentalization-based prevention program to boost well-being for 8–11 year olds and families

  A multi-country program tests whether a family-focused, mentalization-based approach can improve well-being and mental health in primary-school children and their parents.

  Recruiting at 4 sites University Hospital Heidelberg · Heidelberg and 3 other locations · NCT07494929

• Cocreating local actions to make healthcare more rational

  This project will test whether working with residents in Elche to cocreate community actions can reduce unnecessary use of mental‑health drugs, cardiovascular medications, and antibiotics and ease pressure on primary care.

  Recruiting at 2 sites Universidad Miguel Hernandez de Elche · Elche, Alicante and 1 other locations · NCT07237971

• Therapeutic chat and self-help modules to reduce child sexual abuse material use

  This study is testing whether a chat service with a therapist and self-help tools can help people reduce their use of child sexual abuse material and improve their mental health.

  Recruiting Charite University, Berlin, Germany · Berlin and 1 other locations · NCT06852443

• Using light to improve well-being and sleep quality for radiographers

  This study tests if different lighting conditions can help radiographers feel better and sleep more soundly during the darker months of the year.

  Recruiting at 3 sites Lund University · Lund, Skåne County and 2 other locations · NCT06687304

• Using technology to prevent suicide among youth in Colombia

  This study is testing a new technology-based program to help reduce suicidal thoughts and behaviors among young people in Colombian schools.

  Recruiting Brown University · Bogotá, Colombia · NCT06651554

• Park-based youth physical activity program for health promotion

  This study is testing a fun afterschool program in parks that includes sports and nutrition lessons to see if it helps kids aged 6-14 get fitter and feel better mentally.

  Recruiting Duke University · Miami, Florida · NCT06595251

• EviBody: a personalised digital program to support healthy habits and well-being

  This project will test whether the EviBody app helps adults improve and maintain healthy eating, physical activity, mental health, and overall well‑being compared with people not using the app.

  Recruiting Sophiahemmet University · Stockholm · NCT05973383

• Evaluating different overnight duty schedules for ICU residents

  This study tests whether different overnight work schedules for ICU residents can improve patient safety and the learning experience for doctors in training.

  Recruiting The Hospital for Sick Children · Toronto, Ontario and 4 other locations · NCT04176094

NIH-funded research (newest 40 of 142)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Healthy work design and worker well-being

  A multi-site program aims to improve the health and well-being of workers by studying how work design affects safety, stress, and quality of life.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11631666

• Anga Center for Community Health and Well-being

  A community-focused program from Columbia University aims to strengthen mental health and resilience in East Africa and other at-risk communities by partnering with local centers and using evidence-based approaches.

  NIH research Columbia Univ New York Morningside · New York, United States · NIH-11601626

• Anga Center for Community Health and Well-being: building resilience to extreme weather in Africa and beyond

  A program to help communities cope with the mental health effects of extreme weather by partnering with African regions and local centers to develop practical, evidence-based support.

  NIH research Columbia Univ New York Morningside · New York, United States · NIH-11601625

• Air Pollution and Well-Being in Uganda: Understanding Risks and How to Protect Children and Adults

  A short study will explore how biomass smoke affects health and daily life in Uganda and test practical tips to reduce exposure.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11601054

• Air Pollution and Well-Being in Uganda: Reducing Biomass Smoke Risks and Improving Education

  A short project in Uganda will look at how biomass smoke affects health and whether simple education can help families reduce exposure and protect children and adults.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11601048

• Fostering Community Connections to Strengthen Youth Resilience and Well-Being

  A Hawaii-based effort helps teens and young adults get mental health and preventive care more easily by building local networks and smart referral pathways.

  NIH research Waianae Coast Comprehensive Health Ctr · Waianae, United States · NIH-11578589

• Father-inclusive parenting program to boost early child development

  A family-focused program tests whether including fathers in responsive parenting support leads to better outcomes for young children.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11552851

• Long-term Effects of a Natural Disaster on Cognitive Aging and Dementia in Older Adults

  This project follows older adults affected by a major natural disaster to understand how long-term stress may influence aging, memory, and risk for dementia.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11541242

• Activities4Care: a digital assistive platform to boost well-being for people with dementia and their caregivers

  A new digital platform will provide personalized, meaningful activities for people living with dementia to improve mood, behavior, and quality of life, with guidance for caregivers.

  NIH research Plans4care INC. · Providence, United States · NIH-11530760

• Women's social ties and well-being in a resource-limited setting

  A study in rural sub-Saharan Africa will follow midlife women and their relationships with children and family over time to understand how social support affects happiness, self-esteem, and mental health.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11528309

• Music and well-being after an Alzheimer’s diagnosis

  Families and people newly diagnosed with Alzheimer’s or related dementias could discover how engaging with music might support mood, identity, and social connection early on.

  NIH research Northern California Institute/res/edu · San Francisco, United States · NIH-11463476

• Prenatal mindfulness and inflammatory pathways to support mom and baby health

  A study from Oregon Health & Science University will explore how mindfulness during pregnancy might influence inflammatory signals and improve emotional well-being for mothers and healthy development for their children.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11451269

• Yoga for well-being in incarcerated adults across multiple sites

  A multi-site program tests a yoga-based approach to improve mental well-being for adults in prison.

  NIH research Butler Hospital (Providence, Ri) · Providence, United States · NIH-11445342

• Targeting teens’ social media use and real-time chats to improve well-being

  A teen-focused program tests whether reducing social media, boosting real-time conversations, or journaling can improve well-being in 10th graders.

  NIH research West Virginia University · Morgantown, United States · NIH-11443541

• Functioning, Frailty, and Well-being in aging women

  A large NIH grant is funding a study to understand how aging affects physical and mental functioning in women, with the goal of helping maintain independence and quality of life.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11421747

• Air Pollution and Well-Being in Uganda: Reducing Biomass Exposure and Boosting Health Knowledge

  A short study in Uganda will explore how biomass smoke affects health and what people know and do to protect themselves, with plans to share practical tips with communities.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11419190

• Anga Center for Community Health and Well-being: A center to boost mental health resilience in Africa and beyond

  A center-led program will partner with communities in East Africa to develop ways to keep people mentally healthier after extreme weather.

  NIH research Columbia Univ New York Morningside · New York, United States · NIH-11418069

• Protecting East African children and families from harm caused by extreme heat and drought

  Working with East African communities to find practical ways to reduce health harms from heatwaves and drought for children and families.

  NIH research Columbia Univ New York Morningside · New York, United States · NIH-11417052

• Anga Center for community health and well-being in East Africa

  Working with East African communities, researchers will develop community-led ways to protect children and families from heatwaves, droughts, and other extreme weather.

  NIH research Columbia Univ New York Morningside · New York, United States · NIH-11417051

• Improving teen mental health and substance use by changing neighborhood and school policies

  This project uses data from thousands of teenagers to see whether changing neighborhood, school, and peer environments can reduce substance use and improve mental health.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11415849

• Strategies to reduce weight stigma and support diabetes care for adults with type 2 diabetes

  A patient-facing program explores how reducing weight stigma and using self-affirmation can help adults with type 2 diabetes adopt healthier habits and better manage blood glucose.

  NIH research Mainehealth · Portland, United States · NIH-11399876

• Great Lakes Center for Farmworker Health and Well-being

  A center focused on improving the health and well-being of migrant and seasonal farmworkers through research, collaboration, and practical policy changes.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11399482

• Inflammation, High Blood Pressure, and Mom’s Long-Term Well-Being During Pregnancy

  This project looks at how immune changes during pregnancy-related high blood pressure may affect a mother’s brain health and mood, and how it could influence babies after birth.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-11397751

• LEAP: a youth leadership and mindfulness program to support well-being

  A two-arm study will test whether a 7-week LEAP program that combines leadership training with mindfulness can improve mental, emotional, and behavioral well-being for adolescents aged 12–20.

  NIH research Boston University (Charles River Campus) · Boston, United States · NIH-11395595

• Impact of VOCs in Pregnancy on Baby and Mom’s Health

  This project looks at how exposure to airborne chemicals during pregnancy could affect a mom’s health and a baby’s growth and immune system.

  NIH research Wayne State University · Detroit, United States · NIH-11394819

• Pediatricians Building Resilience for Toddler Well-Being

  Aiming to help toddlers at risk for mental health problems by identifying them in primary care and delivering family-based support through an online tool and telehealth.

  NIH research Northwestern University · Chicago, United States · NIH-11394445

• Adolescent social media content and well-being in SGM and non-SGM youth

  Researchers will follow 400 teens over two years to see how what they post and what they see on social media relates to their mood, friendships, and overall well-being.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11393903

• Understanding how technology and social media affect teen health

  This grant studies how teens’ use of digital media and online content influences their health, behavior, and well-being over time.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11393897

• A workplace resilience program to support child care providers’ mental health

  A fully remote, randomized trial will test a web-based Stress Management and Resilience Training (SMART) program to improve mental health and well-being for child care providers.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11381178

• Women’s social ties and well-being in a rural African setting

  This project studies how midlife women in rural sub-Saharan Africa rely on and relate to their children and others, and how these exchanges affect their happiness and mental health.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11380525

• Strengthening Native Hawaiian community ties to support youth resilience and health

  Local health centers, schools, and community groups are using Native Hawaiian cultural practices to help young people build resilience, get mental health support, and stay healthy during and after the COVID-19 era.

  NIH research Waianae Coast Comprehensive Health Ctr · Waianae, United States · NIH-11379177

• How family and community relationships affect midlife women's emotional health in rural Mozambique

  This project follows midlife women in rural Mozambique to learn how support from children, relatives, and others links to their happiness, stress, and mental health.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11379163

• Socially Engaging Virtual Reality for Older Adults with Cognitive Impairment

  A VR-based volunteer program helps older adults with cognitive impairment stay socially connected and improve well-being.

  NIH research Cornell University · Ithaca, United States · NIH-11378456

• How Families Thrive: Understanding How Disasters Affect Parents and Young Children

  This grant explores how disasters and big life risks affect the well‑being of parents and their young children from pregnancy through age 4, using a long‑term study to learn what helps families stay resilient.

  NIH research University of North Carolina Greensboro · Greensboro, United States · NIH-11377487

• Systems modeling to support healthier teen neighborhoods and schools

  A nationwide team will use data from a large study of rural North Carolina students to map how neighborhood, school, and peer factors affect teen substance use and well-being, with plans to test future interventions.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11375088

• How teens' own and others' social media posts relate to emotional well-being

  This project follows 13–15-year-old teens, including sexual and gender minority (LGBTQ+) youth, to see how things they post and things they see on social media relate to their emotional health over time.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11367899

• How technology and social media affect teens' brain, behavior, and well-being

  Researchers are following teens aged 12–20 over time to see how their use of technology and digital media relates to mental health, behavior, and brain development.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11367878

• Women's relationships and well-being in rural Mozambique

  This project follows midlife women in rural Mozambique to learn how help and contact with children, relatives, and neighbors relate to happiness and mental health.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11366958

• How different kinds of social support affect health and well-being for transgender and nonbinary adults

  This project will create a new tool to find which kinds of support help transgender and nonbinary adults feel safer and healthier.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11366166

• Supporting VA healthcare workers during the switch to a new electronic health record

  This project will find ways to keep VA clinicians healthy, reduce burnout, and prevent staff leaving while hospitals switch to a new electronic health record.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11365623

Related topics

Quick answers

How many Well-being clinical trials are recruiting right now?

11, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (3 trials), Germany (3 trials), Spain (3 trials), Sweden (2 trials), Lithuania (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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