Improving decision-making in adults recovering from amphetamine use disorder by enhancing mood
Official title: Modulating explore-exploit biases by improving mood in adults with amphetamine use disorder
Funded at Laureate Institute for Brain Research · NIH-11093606 · Data updated 2026-11-12
This study is looking at how feeling better can help people recovering from amphetamine use make smarter choices, and it uses fun memory exercises to lift their mood while checking how their brains work during decision-making.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Laureate Institute for Brain Research NIH-funded |
| Lab location | 1 site (Tulsa, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $261,706 |
| NIH project number | 5P20GM121312-07 |
| Project ID | NIH-11093606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are currently abstinent from amphetamines and experiencing negative mood states.
✕Less likely to help
Patients who are actively using amphetamines or are not in a state of abstinence may not benefit from this research.
What this research studies
This research investigates how improving mood can help individuals recovering from amphetamine use disorder (MUD) make better decisions. It focuses on the 'explore-exploit' trade-off, where individuals often struggle to choose the best options due to negative feelings associated with their recovery. By using techniques like autobiographical memory recall to boost mood, the study aims to see if this can lead to healthier decision-making patterns. Participants will undergo brain imaging and behavioral tasks to assess changes in their decision-making processes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving decision-making and reducing relapse rates in individuals recovering from amphetamine use disorder.
How similar studies have gone: While the approach of using mood enhancement to improve decision-making in substance use disorders is innovative, similar strategies have shown promise in other areas of addiction treatment.
Where this research is happening
-
Laureate Institute for Brain Research
Tulsa, United States Active
Researchers
- Principal investigator: Gueguen, Maëlle Camille Marie — Laureate Institute for Brain Research
- Study coordinator: Gueguen, Maëlle Camille Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.