Condition

Gut Microbiota clinical trials and research

• 29Clinical trials
• 139NIH research projects
• 12Countries

Newest Gut Microbiota clinical trials

All recruiting trials (29)

• Overnight Temperature Regulation to Test Gut Health, Inflammation, and Circadian Rhythms

  This study tests whether two weeks of using the Eight Sleep Pod at night can improve gut bacteria balance, lower inflammation, and strengthen daily temperature and blood pressure rhythms in postmenopausal women and age-matched men with poor sleep.

  Recruiting Eight Sleep Inc. · Newton Center, Massachusetts · NCT07848594

• Probiotic Y7 cocktail to help with early Parkinson’s symptoms

  A 12-week randomized trial will test whether a probiotic Y7 cocktail helps people with early Parkinson’s disease by possibly improving motor, thinking, and everyday symptoms.

  Recruiting Taipei Medical University · Taipei · NCT07619560

• Novel functional snack and perimenopause: does a fibre- and phytochemical-rich bite help symptoms?

  A daily snack enriched with phytochemicals and fiber is being tested to see if it can reduce perimenopausal symptoms and improve well-being in women aged 40–55 who are not using hormone therapy.

  Recruiting King's College London · London, London · NCT07599930

• Dairy versus plant-based yogurt effects on weight, muscle, bones, and gut bacteria

  This study will test whether eating dairy yogurt instead of a plant-based yogurt (or no yogurt) helps postmenopausal women with overweight or obesity maintain muscle and bone health, control weight, and change gut bacteria.

  Recruiting Laval University · Québec, Quebec · NCT07578103

• Gut-brain in PD Consortium: understanding gut influences in Parkinson's and prodromal stages

  This study tests how the gut and brain communicate in people with Parkinson's, those without PD, and those at risk, to see if gut factors relate to disease onset and progression.

  Recruiting at 4 sites Duke University · Stanford, California and 6 other locations · NCT07567794

• Sustainable and inclusive alternative proteins for Mediterranean diets (CIPROMED)

  This study tests whether breads and other Mediterranean foods made with alternative proteins (like cricket, spirulina, hemp, and legumes) change appetite, fullness, food choices, and metabolic markers in healthy adults and people who are overweight.

  Recruiting University of Bologna · Bologna, BO · NCT07553936

• Pesticide exposure, cell-free DNA, and gut/genital microbiome signatures in women with endometriosis

  This project will test whether pesticide exposure is linked to oxidative-stress-related changes in circulating cell-free DNA and to differences in the gut and genital microbiomes in women with endometriosis and infertility.

  Recruiting Centre Hospitalier Universitaire, Amiens · Salouël · NCT07471373

• Multispecies synbiotic in people on hemodialysis

  This pilot study tests whether a multispecies synbiotic can alter gut microbes and reduce gut-derived toxins in adults on maintenance hemodialysis over 12 weeks.

  Recruiting Tungs' Taichung Metroharbour Hospital · Taichung, Wuqi District · NCT07461233

• Multispecies Synbiotic in hemodialysis patients with CKD

  This pilot study tests whether a multispecies synbiotic can lower gut-derived toxins and reduce inflammation in adults on maintenance hemodialysis.

  Recruiting Tungs' Taichung Metroharbour Hospital · Taichung, Wuqi District · NCT07443280

• PD-1 antibody plus first-line chemotherapy for metastatic gastric cancer and gut bacteria

  This project will try combining a PD-1 antibody with standard first-line chemotherapy in people with advanced gastric cancer to see if gut bacteria predict who benefits.

  Recruiting Fudan University · Shanghai, Shanghai Municipality · NCT07400354

• Bariatric Surgery and Gut Microbiota Changes Over Time

  This study looks at how gut bacteria and stool metabolites change over 12 months after Roux-en-Y gastric bypass in adults with obesity, compared with those treated with diet alone and healthy-weight individuals.

  Recruiting Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis · Castellana Grotte, BA · NCT07381140

• Extensively hydrolysed whey formula with synbiotics and 2'-FL for infants with cow's milk protein allergy

  This study tests whether an extensively hydrolysed whey-based infant formula with synbiotics and the human milk sugar 2'-fucosyllactose (2'-FL) helps infants under 10 months who have suspected or confirmed cow's milk protein allergy.

  Recruiting at 13 sites Outcomes'10 · Valencia, Valencia and 12 other locations · NCT07342621

• Mini-pill to sample gut bacteria after meat versus plant-based meals

  This trial will test whether an ingestible mini‑pill can collect gut samples from men and postmenopausal women ages 50–74 eating diets based on meat or plant‑based meat alternatives.

  Recruiting Tufts University · Boston, Massachusetts · NCT07220369

• Restore a newborn's gut microbiota using the mother's microbes.

  This will test whether giving C-section newborns bacteria from their own mother or commercial probiotics helps their gut microbiota become more like babies born vaginally.

  Recruiting at 2 sites University of Helsinki · Helsinki and 1 other locations · NCT07212361

• Walnuts as a first solid food for breastfed infants

  This trial will test whether introducing small amounts of walnuts during early complementary feeding changes the gut microbiome, inflammation, eczema, and growth in healthy breastfed infants.

  Recruiting Colorado State University · Fort Collins, Colorado · NCT07081698

• How TAVI affects gut bacteria in people with severe aortic stenosis

  This will test whether transcatheter aortic valve implantation (TAVI) changes the gut microbiota and related blood markers in people with severe aortic stenosis.

  Recruiting Hippocration General Hospital · Athens · NCT07052071

• Gut–brain microbiota link in new‑onset and drug‑resistant epilepsy

  This project will see if gut bacteria and their chemical products are linked to how well people with new‑onset or drug‑resistant epilepsy do after surgery, vagus‑nerve stimulation, or a ketogenic diet.

  Recruiting Niguarda Hospital · Milan, Lombardy · NCT07010445

• Lifestyle changes to prevent memory problems in older adults with depression

  This trial will test whether a Mediterranean-style diet, regular supervised exercise, or weekly cognitive training can help prevent memory decline and improve mood in people aged 50–80 with depressive symptoms or major depression but no cognitive impairment.

  Recruiting IRCCS Centro San Giovanni di Dio Fatebenefratelli · Brescia · NCT07009223

• Using organoid models to study liver cancer

  This study is trying to create mini-livers from patients' liver tissue to see how liver cancer behaves and how well different treatments work for people with the disease.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT06929845

• Fiber smoothie before knee revision to see if it lowers inflammation

  A two-week daily whole-food plant-based smoothie is tested to see if it can reduce inflammation in people having knee replacement revision.

  Recruiting Hospital for Special Surgery, New York · New York, New York · NCT06896240

• Daily peanut consumption for improving health in prediabetes

  This study is testing whether eating peanut butter every day can help people with prediabetes improve their health, including blood sugar levels and brain function.

  Recruiting Georgia State University · Atlanta, Georgia · NCT06867198

• Exploring how gut microbiome affects brain health in Alzheimer's disease

  This study is trying to see how the bacteria in our gut might affect brain health in people with Alzheimer's disease and related memory issues.

  Recruiting Jining Medical University · Jining, Shandong · NCT06837272

• Wild blueberry powder for joint and gut health

  This trial will test whether taking 25 g of freeze-dried wild blueberry powder daily for 12 weeks changes gut bacteria, lowers inflammation markers, and improves joint pain in adults with multi-joint or knee arthritis.

  Recruiting University of Nevada, Las Vegas · Oklahoma City, Oklahoma · NCT06828159

• Using blueberries to improve health in women with prediabetes

  This study is testing if eating freeze-dried wild blueberry powder can help improve health, brain function, and gut health in women with prediabetes.

  Recruiting Georgia State University · Atlanta, Georgia · NCT06735651

• Effects of a Single Workout on Gut Health in Women

  This study is testing how a single workout affects gut health and metabolism in premenopausal women of different fitness levels and body types.

  Recruiting George Washington University · Washington D.C., District of Columbia · NCT06691100

• Investigating gut microbiota and immune function in monoclonal gammopathy patients

  This study looks at the gut bacteria and immune system in patients with monoclonal gammopathy to see how they might be affected, especially in those with infections.

  Recruiting Zhujiang Hospital · Guanzhou, Guangdong · NCT06539832

• Investigating gut microbiota in obese patients with type 2 diabetes and infections

  This study looks at how the bacteria in the gut of obese adults with type 2 diabetes might affect their chances of getting chronic infections.

  Recruiting Azienda Ospedaliero Universitaria Maggiore della Carita · Novara, Novara · NCT05975541

• Investigating gut health and nutrition in malnourished Bangladeshi women

  This study is testing how gut health affects malnourished women in Bangladesh and whether a special nutrition plan can improve their health during pregnancy.

  Recruiting International Centre for Diarrhoeal Disease Research, Bangladesh · Dhaka, Dhaka Division · NCT05862363

• Study on mother-infant gut health in Malaysia and China

  This study looks at how the types of bacteria in breast milk from mothers in Malaysia and China might affect their babies' health and development during the first year of life.

  Recruiting Universiti Putra Malaysia · Kajang, Selangor · NCT04919265

NIH-funded research (newest 40 of 139)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Gut microbiome and Parkinson's disease: how gut bugs relate to symptoms and progression

  A multi-year study will look at gut bacteria and related markers in people with Parkinson’s disease to understand how the gut-brain connection may influence symptoms and progression.

  NIH research University of Chicago · Chicago, United States · NIH-11583671

• Gut-Brain Axis in Parkinson’s Disease: biomarkers and procedures to track progression

  A patient-focused program to study how gut health and the brain interact in Parkinson’s disease using biomarkers and clinical procedures.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11582685

• Vitamin D, gut bacteria and dementia risk in older adults with HIV

  This work will look at whether low vitamin D and changes in gut bacteria are linked to higher dementia risk in older adults living with chronic HIV and similar community members.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11517874

• Gut bacteria and lung immune cells shape viral lung infections

  A study explores how gut microbes affect lung immune cells and severity of respiratory viral infections to identify potential ways to reduce illness.

  NIH research Georgia State University · Atlanta, United States · NIH-11449351

• Gut bacteria and Tuft-2 cells linked to early colorectal cancer risk in young Black Americans

  This grant aims to understand how gut microbes and Tuft-2 cells may predict aggressive colon adenomas in young Black adults who develop colorectal cancer.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11425469

• Gut bacteria, HIV, and alcohol: how microbes affect gut health in people with HIV

  This NIH grant studies how alcohol use and HIV together affect the gut’s bacteria and barrier, exploring a possible way to reduce gut inflammation in people living with HIV.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11416474

• Genes, gut bacteria, and choline in atrial fibrillation

  A study exploring how dietary choline, gut microbes, and the chemical TMAO may influence atrial fibrillation and related heart risks in people.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11408653

• Gut bacteria and how they influence alcohol seeking and decisions

  This project looks at whether the bacteria living in the gut affect how people or animals seek alcohol and make decisions about drinking.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11404984

• Gut bacteria changes after bariatric surgery and colorectal cancer risk

  This study will follow adults who had bariatric surgery to understand how changes in the gut microbiome and bile acids might influence colorectal cancer risk.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11401981

• How gut cells talk with gut bacteria to keep digestion balanced

  This grant looks at how intestinal cells influence gut bacteria to keep the gut healthy and minimize inflammation.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11398273

• Gut microbiota and endometriosis: a microbiome-based approach to understanding and treating pain and lesions

  Researchers are studying how the gut microbiome might influence endometriosis to guide new, nonhormonal treatments for symptoms like pelvic pain and infertility.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11391968

• Trauma, the gut, and the brain: how gut microbes and microglia affect brain injury

  A study to understand how gut bacteria and brain immune cells interact after a traumatic brain injury and how this might influence recovery.

  NIH research Northwestern University · Chicago, United States · NIH-11381827

• How a mother's obesity might affect her child’s breast cancer risk through the gut

  This study investigates whether maternal obesity changes a child’s gut bacteria in a way that could increase breast cancer risk later in life.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11375040

• Gut microbiome clues for Parkinson’s disease progression

  A study looks at how gut bacteria and their chemicals relate to Parkinson’s disease over time to find potential biomarkers and new treatment ideas.

  NIH research University of Chicago · Chicago, United States · NIH-11372253

• How gut bacteria change bile acids

  Researchers are using special chemical probes to find which gut bacterial enzymes change bile acids and how those changes matter for human health.

  NIH research Cornell University · Ithaca, United States · NIH-11372245

• Gut-brain connections in Parkinson’s disease and how they relate to disease severity and progression

  A study at Rush University Medical Center will look at how gut health and brain disease interact in people with Parkinson’s to better understand how the illness grows and gets worse.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11372156

• Maternal gut microbiome and how it shapes early brain development and autism-related behaviors

  A study at Baylor Medicine will explore how a mother's gut bacteria during pregnancy may influence a child’s brain development and risk for autism-related behaviors.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11370266

• Gut microbiome and Parkinson's disease

  This project looks at gut bacteria and the chemicals they make in people with Parkinson's disease over time to find patterns linked to symptoms and progression.

  NIH research University of Chicago · Chicago, United States · NIH-11369336

• Indole lactate from gut microbiota could help repair myelin in MS

  A Johns Hopkins team is testing a gut-derived molecule called indole lactate to see if it can promote remyelination and reduce neuroinflammation in multiple sclerosis.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11369086

• Gut-immune links in autoimmune disease via Tfh cells

  A study to understand how certain gut bacteria-related immune cells (Tfh17) may drive autoimmune diseases like RA and lupus.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11367077

• Gut–brain connections in Parkinson's disease

  This project adds gut and brain tests to look for gut-based signs that track Parkinson's disease progression in people living with Parkinson's.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11362899

• Tracking how gut bacteria evolve in real time

  Scientists are building a way to map how gut bacteria change and adapt over days to months in people, using advanced math and computer tools.

  NIH research Stanford University · Stanford, United States · NIH-11360188

• Bioelectric signals linking gut microbes and your body

  A study to understand how electrical signals from gut bacteria communicate with your body and influence health.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11359602

• Gut microbes and multiple sclerosis progression: new clues from 16S sequencing

  This grant explores how gut bacteria may influence how quickly multiple sclerosis progresses and how patients respond to therapies.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11355318

• Bifunctional mucinase and personalized gut microbiota in cholera infection

  A study in people and models to understand how a cholera bacterium interacts with the gut mucous layer and the individual’s own gut microbes during infection.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11348224

• Gut microbiome signals that affect insulin resistance in pregnancy

  A study from the University of Illinois at Chicago will explore how the gut bacteria and a key body sensor called the aryl hydrocarbon receptor influence insulin resistance during pregnancy.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11341237

• Gut microbiome metabolite 3-PPA helps beige fat and energy balance

  A study will look at how a gut-friendly chemical called 3-PPA may boost beige fat to burn calories and improve blood sugar in adults with type 2 diabetes risk.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-11341044

• Gut microbiome and heart/metabolic disease influence

  A large NIH grant is exploring how gut bacteria affect common heart and metabolic diseases and how we might use that knowledge to improve health.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11335422

• Gut bacteria that may change how severe malaria becomes

  This work looks at whether certain gut bacteria make malaria worse in children and could point to ways to lower the risk of severe malaria.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11333271

• Vitamin D, gut bacteria, and dementia risk in older adults with HIV

  This project looks at whether vitamin D levels and differences in gut bacteria are linked with dementia risk in older adults living with long-term HIV and in similar people without HIV.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11326348

• How gut bacteria and the gut lining interact in celiac disease

  This project looks at how specific gut microbes and the substances they make affect the gut lining and immune system in people with or at high risk for celiac disease.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11324586

• Processed foods, gut bacteria, and immune defenses in inflammatory bowel disease

  This project tests whether an ultra‑processed food–style diet changes gut bacteria and weakens immune defenses in people at risk for inflammatory bowel disease.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11322034

• Gut bacteria stability in ulcerative colitis and Crohn’s disease

  Researchers are tracking gut bacteria over several years in people with ulcerative colitis and Crohn’s disease (and healthy volunteers) to see whether long-term bacterial stability links to flares and outcomes after fecal transplants.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11296873

• How eating a lot of sugar changes the gut's bacteria

  This project looks at how high-sugar diets change common gut bacteria and how those changes might affect gut inflammation and colorectal cancer risk.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11293449

• Minocycline to lower hard-to-control high blood pressure by targeting the gut–brain–immune link

  Looks at whether the antibiotic minocycline can help people with resistant high blood pressure by changing gut bacteria and calming inflammation that affects the brain and immune system.

  NIH research University of Florida · Gainesville, United States · NIH-11292408

• How gut bacteria chemicals help intestinal cells calm immune responses in the gut

  This research looks at how chemicals made by gut bacteria help intestinal cells communicate with immune cells to reduce inflammation in people with inflammatory bowel disease.

  NIH research Northwestern University · Chicago, United States · NIH-11290386

• Sleep, gut microbes, and early weight gain in young children

  A study to understand how sleep patterns and gut bacteria together influence rapid weight gain in babies and toddlers.

  NIH research Colorado State University · Fort Collins, United States · NIH-11289878

• Gut microbes, fiber in your diet, and inflammatory bowel disease

  This grant explores how dietary fiber and gut bacteria influence inflammatory bowel disease and related inflammation in people and models.

  NIH research Georgia State University · Atlanta, United States · NIH-11288589

• Vancomycin changes gut bacteria to protect the heart via microRNA-204

  Using the antibiotic vancomycin to change gut bacteria, the team aims to protect people whose left heart is under pressure from conditions like high blood pressure or aortic valve narrowing.

  NIH research University of Iowa · Iowa City, United States · NIH-11287895

• Gut microbiota fucosylation and alcohol-related liver disease progression

  A small, patient-friendly study will explore how alcohol-related changes in the gut’s sugar decorations (fucosylation) may drive liver disease over time.

  NIH research University of Louisville · Louisville, United States · NIH-11287540

Related topics

Quick answers

How many Gut Microbiota clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 12 countries. The most sites are in United States (9 trials), Italy (6 trials), Taiwan (3 trials), China (3 trials), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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