Condition

Metabolomics clinical trials and research

• 13Clinical trials
• 134NIH research projects
• 10Countries

Newest Metabolomics clinical trials

All recruiting trials (13)

• Barley and kefir to support gut health in active adults

  This study tests whether a daily barley and kefir meal for four weeks can change gut microbiota in physically active adults and whether those changes relate to certain metabolites in blood and urine.

  Recruiting Western Norway University of Applied Sciences · Bergen · NCT07864779

• How gut microbes affect blueberry polyphenol metabolites in healthy adults

  This study tests whether differences in the gut microbiome change how healthy adults metabolize blueberry polyphenols after a single blueberry dose.

  Recruiting Colorado State University · Fort Collins, Colorado · NCT07607158

• Virtual approaches for period pain in young women

  This study tests two online self-care options—auricular acupressure and Baduanjin qigong—against a self-care education group to see if they reduce menstrual pain and related symptoms in young women.

  Recruiting Phase 2/3 Nanyang Technological University · Singapore · NCT07497711

• Brain and metabolic responses to different macronutrients in people with obesity

  This trial will test whether three small, isocaloric liquid meals (glucose, fat, or protein) change brain activity and blood metabolites in adults with obesity and healthy-weight adults.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT07392905

• Scalp hair chemical changes in people with severe obesity and after bariatric surgery

  This project will see if chemicals trapped in scalp hair change with body weight and can signal hair thinning or muscle loss in adults having bariatric surgery.

  Recruiting Singapore General Hospital · Singapore · NCT07368842

• Epilepsy and gut and mouth bacteria: linking microbiota to seizure medicine response

  This project will test whether differences in gut and mouth bacteria are linked to epilepsy type and change how well seizure medicines work in people newly diagnosed with epilepsy compared with healthy volunteers.

  Recruiting at 6 sites Karolinska Institutet · Gothenburg and 5 other locations · NCT07253701

• Omega-3 supplements added to standard TB treatment in adults with pulmonary TB

  This trial tests whether adding omega-3 EPA and DHA to standard TB therapy for 8 weeks helps kill the bacteria faster and reduce inflammation in adults with new, drug-sensitive pulmonary TB.

  Recruiting Phase 2 North-West University, South Africa · Klerksdorp, North West · NCT07118059

• Daily intake of short-chain fatty acids and its effects on metabolic health

  This study is testing whether drinking a daily beverage with short-chain fatty acids can help people at risk for metabolic syndrome improve their heart and metabolic health over 12 weeks.

  Recruiting KU Leuven · Leuven, Vlaams-Brabant · NCT06951386

• Longitudinal analysis of lung cancer using tissue and blood samples.

  This study is trying to see if changes in blood and tissue samples from lung cancer patients can help doctors tell the difference between harmless and harmful lung nodules and improve treatment plans.

  Recruiting The First Affiliated Hospital of Guangzhou Medical University · Guangzhou, Guangdong · NCT06843707

• Exploring how methylphenidate affects brain activity and metabolism in children with ADHD

  This study is testing how the medication methylphenidate affects brain activity and metabolism in children with ADHD to see if it can help improve their treatment.

  Recruiting National Taiwan University Hospital · Taipei · NCT06073470

• Using supplemental oxygen to treat pulmonary embolism

  This study is testing if giving extra oxygen to people with acute pulmonary embolism can help their heart function better and improve their overall health.

  Recruiting Early Phase 1 Massachusetts General Hospital · Boston, Massachusetts · NCT05891886

• Exploring the role of LPC16:0 in fibromyalgia

  This study is trying to see how a specific compound called LPC16:0 affects people with fibromyalgia to help find better ways to diagnose and treat the condition.

  Recruiting Kaohsiung Medical University Chung-Ho Memorial Hospital · Kaohsiung City · NCT04832100

• Study on muscle weakness after surgery in intensive care patients

  This study is testing if changes in blood and muscle samples from surgical patients can help us understand and find markers for muscle weakness that happens after being in intensive care.

  Recruiting Technical University of Munich · Vienna, State of Vienna and 2 other locations · NCT03810768

NIH-funded research (newest 40 of 134)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Newborn screening: using gene and metabolite data to refine true vs false positives

  A study using genetic and metabolomic data from newborn blood spots to better distinguish real metabolic disorders from false alarms.

  NIH research Yale University · New Haven, United States · NIH-11608554

• IDEAL: How early-life immune development shapes vaccine responses and asthma risk

  A child-focused project that looks at how the developing immune system in early life affects vaccine responses, respiratory infections, and asthma.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11496688

• Integrative metabolomics to improve sarcoidosis diagnosis and prognosis

  A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11496248

• Metabolomics clues to how ultra-processed foods affect risk of type 2 diabetes

  A scientist-led study will look at how eating different ultra-processed foods may change diabetes risk by using a controlled feeding trial and big population data, focusing on adults.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11447975

• Longitudinal metabolomics in infants with food allergies

  A study in infants aims to understand how gut metabolites relate to the development of food allergies, including IgE-mediated and non-IgE cases.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11440939

• Biospecimen, Metabolomics, and Pathology Core for Endometrial Cancer Research

  A national, multi-institutional resource collects and analyzes tissue, blood, and metabolites from endometrial cancer patients to support multiple research projects.

  NIH research Washington University · Saint Louis, United States · NIH-11421871

• Metabolomics core to map liver metabolism in liver cancer

  A core facility will measure liver metabolism and metabolic flux to help understand how liver cancer develops and to guide new treatments.

  NIH research Sanford Burnham Prebys Medical Discovery Institute · La Jolla, United States · NIH-11418970

• Metabolomics-powered AI platform to find new cancer drug helpers

  A new AI-powered platform uses metabolomics and machine learning to discover drugs that make cancer cells more sensitive to treatment.

  NIH research Sinopia Biosciences, INC. · San Diego, United States · NIH-11418364

• Understanding COPD by linking genes, metabolites, and the body’s signals

  A study using blood and lung data to map how genetic factors and metabolism drive COPD, with the goal of finding new targets for treatment.

  NIH research University of Virginia · Charlottesville, United States · NIH-11413749

• Proteomics and Metabolomics Resources to Fuel Cancer Research

  A shared proteomics and metabolomics facility at leading cancer centers provides advanced analyses to support cancer research and other biomedical studies.

  NIH research Wistar Institute · Philadelphia, United States · NIH-11411317

• Metabolomics insights to fight chronic graft-versus-host disease

  These researchers are studying why chronic graft-versus-host disease occurs after stem cell transplants and how metabolic changes in immune cells relate to lung and other organ damage, with the goal of guiding better therapies for patients who have or are at risk for cGVHD.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11411261

• Integrative model of metabolites, equol, and heart disease

  This grant looks at how a person’s body processes soy isoflavones into equol and how that relates to atherosclerotic heart disease, using complex data to build predictive models.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11411180

• Biomarker discovery in colon cancer with advanced metabolomics

  A new project will use advanced chemical analysis to find blood- and tissue-based markers that indicate colon cancer and its progression.

  NIH research Panome Bio INC · Saint Louis, United States · NIH-11404018

• A user-friendly machine-learning platform to reveal unknown metabolites in MS-based metabolomics

  A Princeton-led project will create smart computer tools to identify unknown small molecules found in human samples using mass spectrometry, with potential benefits for health research.

  NIH research Princeton University · Princeton, UNITED STATES · NIH-11400086

• Nano-scale sensors to map single cells and mini-tumors metabolism and drug movement

  A Purdue-led project will develop tiny electrochemical sensors to measure many cellular metabolites and how drugs move over time in individual cells and small cell clusters.

  NIH research Purdue University · West Lafayette, United States · NIH-11392301

• Deep Ovarian Cancer Metabolomics

  A study to understand the chemical changes in blood and ovarian tissue from ovarian cancer in mouse models, with the goal of finding biomarkers that could help detect the disease earlier in people.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11391144

• Metabolomics Workbench: A central data hub for patient-related metabolomics information

  A nationwide data repository collects and shares metabolomics data from many studies to help researchers understand health and disease.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11385449

• Metabolomics clocks: a new way to study aging mechanisms

  A patient-facing look at how tiny molecules in the body could help us understand why aging happens and how it links to health and disease.

  NIH research Tufts University Boston · Boston, United States · NIH-11384842

• A universal, cloud-based data hub for metabolomics data processing

  A cloud-based workflow and shared database will harmonize and standardize metabolomics data from different labs to make results more reliable and easier to interpret for biomedical researchers.

  NIH research University of California at Davis · Davis, United States · NIH-11382889

• Metabolomics approach to uncover how age-related macular degeneration develops

  A patient-facing look at how we study small molecules in blood and eye tissue to understand why people develop AMD and how it progresses.

  NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11380958

• Redox, Environment, and Metabolomics links to heart health in people with substance use

  A study using blood samples and health data to explore how certain chemicals in the blood relate to heart disease risk, especially in people who use substances.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11379118

• Bioinformatics platform to map and identify metabolites at scale

  A modern software platform will help scientists find and characterize small molecule metabolites in large datasets to better understand medications, environmental chemicals, and health risks.

  NIH research Ometa Labs LLC · Carlsbad, United States · NIH-11379108

• How early-life metal exposure may shape children's sleep through tiny blood particles

  This project looks at whether metal exposure before and after birth changes sleep patterns in children by altering tiny particles in the blood.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11378304

• Metabolomics insights into health disparities in Native Hawaiian adults

  This study looks at blood metabolites to understand why Native Hawaiian adults experience higher rates of diabetes and heart-related conditions.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11378016

• Why gestational diabetes risk varies among Asian American pregnant people

  This project looks at how metabolism, lifestyle, and social factors relate to gestational diabetes risk in Asian American pregnant people.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11371346

• Advancing spatial metabolism mapping in cancer with METASPACE

  A patient-friendly overview: this grant aims to improve how we map where cancer-related molecules are inside tumors to better understand and treat cancer.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11369957

• Understanding How Body Chemistry, Environment, and Metabolism Affect Disease

  This work explores how changes in our body's chemistry, our surroundings, and how our body uses energy might lead to various health conditions.

  NIH research Louisiana State Univ Hsc Shreveport · Shreveport, United States · NIH-11366953

• Metabolomics clues to osteoporosis risk in diverse populations

  A study using small molecules in blood samples to understand osteoporosis risk, with a focus on aging, ethnicity, and sex differences.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11365802

• Metabolomics in ICH recovery to help understand outcomes

  A study using blood samples from stroke patients who had brain hemorrhages to find metabolic patterns linked to recovery, with a focus on Black and Hispanic communities.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11362207

• AHEAD: How early-life diet shapes kids’ health and teeth

  A study will look at what kids eat and how it changes their health and teeth over time by using metabolomics to build a healthy-eating index for children.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11356836

• Advanced Multiplexed UPLC-MS/MS System to Profile Metabolites

  A grant to upgrade and expand a high-throughput metabolomics platform that measures hundreds of metabolites, helping researchers understand metabolic differences in patients with diseases.

  NIH research University of Washington · Seattle, United States · NIH-11338680

• Orbitrap Astral Mass Spectrometer for Cornell's Proteomics and Metabolomics Facility

  A new high-end mass spectrometry system will be purchased and shared across Cornell to accelerate life science research in proteomics and metabolomics.

  NIH research Cornell University · Ithaca, United States · NIH-11338275

• High-throughput, multiscale imaging of metabolism with AI help

  Aims to create faster, smarter imaging tools that map where metabolites are in tissues, using AI to guide data collection and analysis, with potential benefits for understanding diseases.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11331540

• Advanced tools to map metals and metabolites in cells and to edit DNA with DNAzymes and aptamers

  A research project to create new DNA-based tools that map metals and metabolites inside living cells and tissues and to test a novel DNA-based approach for precise DNA editing.

  NIH research University of Texas at Austin · Austin, United States · NIH-11331460

• Prenatal metabolite patterns linked to early childhood growth and obesity risk

  This project looks at small molecules in pregnant mothers' blood over time to find patterns that predict which children may gain weight quickly or develop overweight/obesity.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11326185

• Epigenomic and Metabolomic Clues to Early and Ongoing Vascular and Heart Disease

  This grant supports a multi-omic study at Emory to find molecular clues in blood and tissues that predict and explain early and clinical vascular disease and heart failure, especially in South Asians.

  NIH research Emory University · Atlanta, United States · NIH-11323896

• Mapping cell lipids to find new treatment targets

  This project develops ultra-high-resolution ways to map fats inside cells to find targets that could help people with drug-resistant cancers and other diseases linked to lipid problems.

  NIH research Louisiana State Univ A&m Col Baton Rouge · Baton Rouge, United States · NIH-11317169

• Metabolomics-Driven Drug Discovery Platform for Better Medicines

  A research project aims to create and validate a new metabolomics-based method to help discover and optimize drugs using advanced AI and high-throughput data.

  NIH research Sinopia Biosciences, INC. · San Diego, United States · NIH-11316610

• User-friendly tools to find disease-related molecules for cancer and other conditions

  This project builds free, easy-to-use online tools that help researchers spot small molecules linked to cancer and other diseases so tests and treatments can improve.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11312629

• Bile acids and gut graft‑versus‑host disease

  Researchers will measure bile acids and related metabolites to find how they affect gut graft‑versus‑host disease in people who’ve had allogeneic stem cell transplants.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11310114

Related topics

Quick answers

How many Metabolomics clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 10 countries. The most sites are in China (2 trials), United States (2 trials), Singapore (2 trials), Taiwan (2 trials), South Africa (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1, Phase 2/3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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