Redox, Environment, and Metabolomics links to heart health in people with substance use
Official title: Redox, Environmental, and Metabolomics: investigating Disease Yield (REMEDY)
Funded at Louisiana State Univ Hsc Shreveport · NIH-11379118 · Data updated 2026-11-12
A study using blood samples and health data to explore how certain chemicals in the blood relate to heart disease risk, especially in people who use substances.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | February 1, 2018 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $196,583 |
| NIH project number | 5P20GM121307-09 |
| Project ID | NIH-11379118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with SUD or at risk for CVD who are able to provide plasma samples and participate in observational analyses.
✕Less likely to help
Patients without substance use disorder or cardiovascular risk factors may have limited direct benefit.
What this research studies
This project will look at how plasma volatile organic compounds (VOCs) and oxidative balance scores relate to cardiovascular risk in people with substance use disorder (SUD). Researchers will analyze large health data and a clinical cohort to measure VOCs, 8-OHdG, and other markers of oxidative stress in about 800 patients, and compare those with and without SUD and with and without cardiovascular disease. The aim is to identify biomarkers that could help predict who is at higher risk for heart problems and to build a centralized database for future research. The work will generate preliminary data to support a future larger grant.
Why it matters
Potential benefit: If successful, this could lead to earlier identification of people at higher cardiovascular risk due to substance use and inform personalized prevention strategies.
How similar studies have gone: Previous studies have linked oxidative stress and certain biomarkers to cardiovascular risk, with ongoing exploration of VOCs as potential indicators.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Bhuiyan, Mohammad Alfrad Nobel — Louisiana State Univ Hsc Shreveport
- Study coordinator: Bhuiyan, Mohammad Alfrad Nobel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.