Exploring how methylphenidate affects brain activity and metabolism in children with ADHD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationship between changes in brain electrophysiology and metabolomics in children with ADHD undergoing treatment with methylphenidate. Over a 12-week period, the study will compare the effects of the medication on children diagnosed with ADHD against neurotypical controls. The goal is to identify biomarkers that can predict which children will respond positively to methylphenidate, as well as to understand the metabolic mechanisms involved in these responses. By elucidating these relationships, the study seeks to enhance treatment strategies for ADHD.

Why it matters

Who can join: the full rules

1. Patients with ADHD

   1. Inclusion Criteria

      * Patients, aged 6 to 18 years, meet the DSM-5 diagnostic criteria for ADHD.
      * At baseline, patients have a Clinical Global Impressions-ADHD-Severity (CGI-ADHD-S) score greater than 4.
      * Patients have a Full IQ (FIQ) score greater than 80.
   2. Exclusion Criteria

      * Patients have a major psychiatric disorder, such as autism spectrum disorder, schizophrenia, affective disorders, or substance use disorders.
      * Patients have a major disorder of central nervous system, such as epilepsy.
      * Patients have a major systemic disease, such as diabetes mellitus or cardiovascular diseases.
      * Patients have ever received any medication to treat the clinical symptoms of ADHD.
2. Neurotypical participants:

   1. Inclusion Criteria

      * aged 6 to 18 years
      * All of the neurotypical participants have no psychiatric disorder in lifetime according to the diagnostic criteria of DSM-5.
   2. Exclusion Criteria

      * participants have any disorder of central nervous system or major systemic disease
      * participants have ever taken any psychotropic drug, or who have FIQ scores less than 80, will be excluded from the present study.

Where it's running

• National Taiwan University Hospital
  Taipei, Taiwan Recruiting

Study contacts

• Study coordinator: Chi-Yung Shang, MD, PhD
• Email: cyshang@ntu.edu.tw
• Phone: +886-2-23123456

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Barley and kefir to support gut health in active adults

  This study tests whether a daily barley and kefir meal for four weeks can change gut microbiota in physically active adults and whether those changes relate to certain metabolites in blood and urine.

  Recruiting Western Norway University of Applied Sciences · Bergen · NCT07864779

• How gut microbes affect blueberry polyphenol metabolites in healthy adults

  This study tests whether differences in the gut microbiome change how healthy adults metabolize blueberry polyphenols after a single blueberry dose.

  Recruiting Colorado State University · Fort Collins, Colorado · NCT07607158

• Virtual approaches for period pain in young women

  This study tests two online self-care options—auricular acupressure and Baduanjin qigong—against a self-care education group to see if they reduce menstrual pain and related symptoms in young women.

  Recruiting Phase 2/3 Nanyang Technological University · Singapore · NCT07497711

• Brain and metabolic responses to different macronutrients in people with obesity

  This trial will test whether three small, isocaloric liquid meals (glucose, fat, or protein) change brain activity and blood metabolites in adults with obesity and healthy-weight adults.

  Recruiting The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Nanjing, Jiangsu · NCT07392905

• Scalp hair chemical changes in people with severe obesity and after bariatric surgery

  This project will see if chemicals trapped in scalp hair change with body weight and can signal hair thinning or muscle loss in adults having bariatric surgery.

  Recruiting Singapore General Hospital · Singapore · NCT07368842

• Epilepsy and gut and mouth bacteria: linking microbiota to seizure medicine response

  This project will test whether differences in gut and mouth bacteria are linked to epilepsy type and change how well seizure medicines work in people newly diagnosed with epilepsy compared with healthy volunteers.

  Recruiting at 6 sites Karolinska Institutet · Gothenburg and 5 other locations · NCT07253701

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.