Metabolomics insights to fight chronic graft-versus-host disease
Official title: Metabolomics of cGVHD
Funded at Dana-Farber Cancer Inst · NIH-11411261 · Data updated 2026-11-12
These researchers are studying why chronic graft-versus-host disease occurs after stem cell transplants and how metabolic changes in immune cells relate to lung and other organ damage, with the goal of guiding better therapies for patients who have or are at risk for cGVHD.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2022 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $580,298 |
| NIH project number | 5P01HL158505-05 |
| Project ID | NIH-11411261 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults affected by chronic graft-versus-host disease after allogeneic stem cell transplantation, including those with bronchiolitis obliterans.
✕Less likely to help
Patients without cGVHD or those who are not candidates for the proposed metabolic-targeted therapies may not benefit.
What this research studies
This grant focuses on understanding the metabolic needs of immune cells involved in chronic GVHD, especially T cells and B cells, and how these changes influence tissue damage like bronchiolitis obliterans. The team is using models and patient-derived data to identify metabolic targets that could improve existing therapies and reduce organ injury. The work aims to translate findings into new combination drug strategies that spare healthy lung tissue and support repair. If successful, the project could lead to earlier and more effective treatments for people living with cGVHD after transplant.
Why it matters
Potential benefit: Potentially new, more effective treatments that reduce organ damage and improve survival for patients with cGVHD after transplant.
How similar studies have gone: Previous work has led to several new therapies for cGVHD and demonstrated feasibility of targeting immune cell metabolism in related conditions.
Where this research is happening
-
Dana-Farber Cancer Inst
Boston, United States Active
Researchers
- Principal investigator: Blazar, Bruce R — Dana-Farber Cancer Inst
- Study coordinator: Blazar, Bruce R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.