Metabolomics core to map liver metabolism in liver cancer
Official title: Core 1: Metabolomics
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-11418970 · Data updated 2026-11-12
A core facility will measure liver metabolism and metabolic flux to help understand how liver cancer develops and to guide new treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 9, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $161,850 |
| NIH project number | 5P01CA281819-03 |
| Project ID | NIH-11418970 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with hepatocellular carcinoma or at risk of liver disease progression who may benefit from metabolic-targeted therapies or biomarker-guided treatment.
✕Less likely to help
Patients without liver cancer or related metabolic dysregulation may not directly benefit from this core.
What this research studies
This grant funds Core 1 to quantify metabolites and track labeled nutrients in liver cells, tissues, and plasma, supporting multiple projects in the program. It provides analytical services, expert guidance on experimental design, and interpretation of results to map the metabolic landscape of hepatocellular carcinoma (HCC). Researchers will study pathways like glycolysis, fatty acid synthesis, cholesterol and bile acid metabolism, and more, using in vitro cultures, tissue slices, and in vivo samples. The goal is to uncover metabolic patterns that differ from normal liver metabolism and could point to new therapeutic strategies. By identifying metabolic vulnerabilities in HCC, this core could help translate metabolic findings into treatments for patients with liver cancer.
Why it matters
Potential benefit: If successful, patients with liver cancer could benefit from new metabolic targets and metabolic biomarker strategies that inform therapy.
How similar studies have gone: Previous metabolic studies in liver cancer have revealed actionable pathways, suggesting this approach could yield meaningful advances.
Where this research is happening
-
Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Scott, David Anderson — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Scott, David Anderson
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.