Metabolomics in ICH recovery to help understand outcomes
Official title: Metabolomics of ICH recovery (METABOL-ICH)
Funded at University of Cincinnati · NIH-11362207 · Data updated 2026-11-12
A study using blood samples from stroke patients who had brain hemorrhages to find metabolic patterns linked to recovery, with a focus on Black and Hispanic communities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | May 15, 2025 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $634,454 |
| NIH project number | 5R01NS140155-02 |
| Project ID | NIH-11362207 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who experienced intracerebral hemorrhage, with emphasis on Black and Hispanic individuals, and matched controls with available plasma samples.
✕Less likely to help
Patients without ICH or those without available samples or 90-day outcome data may not directly benefit.
What this research studies
This project will analyze metabolic profiles from stored samples of ICH patients and matched controls to identify biomarkers associated with poor outcomes. It uses a comprehensive metabolomics approach on data from diverse cohorts (ERICH and ROSE) to uncover pathways involved in recovery. The findings could point to new targets for therapies that improve recovery after intracerebral hemorrhage. The work builds on existing patient data, with careful attention to race/ethnicity and geographic representation. Participants’ data come from multiple sites across the United States and include clinical and imaging information.
Why it matters
Potential benefit: If successful, the research could lead to new metabolic targets for therapies that improve recovery after brain hemorrhage, potentially reducing disability.
How similar studies have gone: Previous metabolomic studies in stroke have identified meaningful biomarkers; this project extends those findings to diverse populations with a large, well-characterized sample set.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Demel, Stacie — University of Cincinnati
- Study coordinator: Demel, Stacie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.