Longitudinal metabolomics in infants with food allergies
Official title: Longitudinal metabolomics of FPIAP and IgE-mediated food allergy in a large infant cohort
Funded at Univ of North Carolina Chapel Hill · NIH-11440939 · Data updated 2026-11-12
A study in infants aims to understand how gut metabolites relate to the development of food allergies, including IgE-mediated and non-IgE cases.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 5, 2026 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $327,727 |
| NIH project number | 1R21AI202343-01 |
| Project ID | NIH-11440939 on NIH RePORTER |
Who could benefit from this research
✓Could help
Infants and young children (0-11 years) who have or are at risk for IgE-mediated or non-IgE-mediated food allergies.
✕Less likely to help
Children without food allergies or those not contributing samples may not benefit directly.
What this research studies
This project will use a large group of infants with stored samples and clinical data to explore how intestinal metabolites like short-chain fatty acids and bile acids correlate with allergic outcomes. Researchers will analyze blood and stool samples over time, along with immune cell profiles, to see how these metabolites influence immune development related to food allergy. The goal is to identify biological pathways that could be targeted to prevent or treat food allergies in early childhood.
Why it matters
Potential benefit: If successful, the work could reveal metabolic targets or biomarkers to prevent or better manage food allergies in young children.
How similar studies have gone: Preliminary evidence links gut metabolites to allergy risk, but this study extends that work with a rich, longitudinal infant cohort.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Virkud, Yamini V — Univ of North Carolina Chapel Hill
- Study coordinator: Virkud, Yamini V
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.